Scientist, Targeted LNP Delivery

Overview

We are seeking a highly motivated, enthusiastic, and innovative scientist to join our LNP group to expand delivery to extra-hepatic tissues of interest. The candidate will innovate and develop LNP delivery solutions suitable for clinical development. The successful candidate will have strong background in nanoparticles with a creative mindset, independent problem-solving ability, collaborative, and desire to enable discoveries at the bench.

This lab-based position is onsite and will be primarily located at 675 W Kendall St, Cambridge, MA 02142.

Key Responsibilities

• Optimize LNP composition and develop and implement ligand bioconjugation strategies with various ligands.
• Troubleshoot and develop analytical methods to screen LNPs for a desired phenotype.
• Work closely with broader platform teams to develop project plans and coordinate activities.
• Analyze, interpret, and organize data to prepare clearly articulated experimental reports and communicate the results of the projects to cross-functional teams.
• Maintain electronic lab notebook, SOPs, appropriate documentation for scientific data and experimental protocols.

Qualifications

• Ph.D. in Chemical Engineering, Chemistry, Pharmaceutical Sciences, or related discipline with 1-2 years of industrial or post-doctoral experience with a focus on LNP formulation and delivery systems.
• Direct experience in LNP formulation (in-line mixing or TFF), characterization (DLS, NTA, zeta potential, UV/fluorescence spectroscopy, HPLC, UPLC, ribogreen assay, capillary electrophoresis, gel electrophoresis, etc.), mRNA and siRNA encapsulation, and bioconjugation is required.
• Experience in targeted LNP or antibody conjugation/post-insertion will be desirable.
• Experience in lipid chemistry and synthesis will be plus.
• Strong team player with excellent verbal and written communication skills.
• Ability to work on multiple projects simultaneously and deliver conclusive results.
• Ability to quickly adapt to new priorities with responsibility in a fast-paced, dynamic, innovative environment.
• Goal oriented, highly organized with significant attention to detail while maintaining highest scientific and ethical standards.

About Alnylam

We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.