Scientist, Target Discovery & Validation
Alnylam Pharmaceuticals
June 30, 2026
On-site
Cambridge, MA
Clinical Research and Development
Key Responsibilities
- Work closely with human genetics, multi-omics, platform and clinical teams to identify promising novel targets.
- Contribute to target identification efforts based on human genetics, literature, academic collaborations, and genomic approaches.
- Design and execute proof of concept experiments in animal and in vitro disease models.
- Design studies, coordinate activities, and lead from the bench.
- Oversee lead discovery activities for selection of drug candidates for further development.
- Develop assays to monitor target engagement/pharmacodynamic responses.
- Manage relationships with CROs and/or academic collaborators, including research plan development and data analysis.
- Mentor junior scientists.
- Collaborate and communicate results with key stakeholders.
Qualifications
- PhD in biology or biomedical sciences-related field.
- Post doc or 1–2 years of experience strongly preferred.
- Strong publication record.
- Preferred: focus on disease biology and prior experience with mammalian disease models.
- Plus: experience using human genetics to support biological mechanisms.
- Must have solid organizational skills and ability to multitask.
- Strong interpersonal/communication skills; track record working on teams; interest in learning new biology; passion for lab work.
Benefits
- Eligible for annual short-term incentive award and annual long-term incentive award.
- Medical, dental, and vision; life and disability insurance; lifestyle reimbursement; flexible spending and health savings accounts; 401(k) with company match; paid time off, wellness days, holidays, and two recharge breaks.
Onsite role primarily located in Cambridge, MA.
- Work closely with human genetics, multi-omics, platform and clinical teams to identify promising novel targets.
- Contribute to target identification efforts based on human genetics, literature, academic collaborations, and genomic approaches.
- Design and execute proof of concept experiments in animal and in vitro disease models.
- Design studies, coordinate activities, and lead from the bench.
- Oversee lead discovery activities for selection of drug candidates for further development.
- Develop assays to monitor target engagement/pharmacodynamic responses.
- Manage relationships with CROs and/or academic collaborators, including research plan development and data analysis.
- Mentor junior scientists.
- Collaborate and communicate results with key stakeholders.
Qualifications
- PhD in biology or biomedical sciences-related field.
- Post doc or 1–2 years of experience strongly preferred.
- Strong publication record.
- Preferred: focus on disease biology and prior experience with mammalian disease models.
- Plus: experience using human genetics to support biological mechanisms.
- Must have solid organizational skills and ability to multitask.
- Strong interpersonal/communication skills; track record working on teams; interest in learning new biology; passion for lab work.
Benefits
- Eligible for annual short-term incentive award and annual long-term incentive award.
- Medical, dental, and vision; life and disability insurance; lifestyle reimbursement; flexible spending and health savings accounts; 401(k) with company match; paid time off, wellness days, holidays, and two recharge breaks.
Onsite role primarily located in Cambridge, MA.