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(Scientist) Sr. Scientist, Cardiovascular and Metabolic Disease

Flagship Pioneering
August 28, 2026
Full-time
Remote friendly (Cambridge, MA)
Worldwide
Clinical Research and Development
Role: Lead and support discovery efforts in cardiovascular and metabolic diseases, focusing on target validation, mechanistic studies, and translational biology to advance novel therapeutics. Responsibilities include designing and executing in vitro and in vivo models, integrating proteomic and computational data, and collaborating with platform scientists to identify high-potential targets. The role involves guiding research strategy, interpreting large datasets, and contributing to pipeline development through scientific leadership and cross-functional teamwork. Qualifications require a Ph.D. in physiology, pharmacology, or related fields, with at least 2 years (Scientist) or 5+ years (Senior Scientist) experience in biotech or pharma, proficiency in cellular and molecular assays (e.g., CRISPR, qPCR, Western blotting), and a strong publication record. Preferred expertise includes knowledge of obesity, diabetes, atherosclerosis, or vascular disease, and experience with translational models such as human tissues, iPSC, or organoids. The position emphasizes scientific innovation, collaboration, and communication skills in a fast-paced environment. High-value specifics: focus on cardiovascular and metabolic disease biology, mechanistic and pharmacology research, and translational science. The role may involve cross-functional, internal and external collaborations, with location and travel details not specified.