Scientist, Solid Tumor CAR-T
Legend Biotech
August 13, 2026
On-site
Philadelphia, PA
Clinical Research and Development
Role Overview
Scientist to join an interdisciplinary cell therapy team advancing CAR-T cell therapies for solid tumors; central to the in vivo CAR-T platform and will drive preclinical development from construct design through animal model efficacy studies.
Key Responsibilities
- Design and execute in vitro functional assays.
- Perform binder selection for CAR design.
- Handle and engineer human and murine T cells.
- Engineer and maintain cancer cell lines for model development.
- Analyze and interpret data, troubleshoot, and present/engage internal stakeholders.
- Maintain detailed experimental records; contribute to scientific reports, presentations, and patent documentation.
Requirements
- PhD in Immunology, Immuno-Oncology, Tumor Immunology, Cancer Biology, or closely related field.
- Up to 3 years postdoctoral experience (PhD completed within past 3 years strongly encouraged).
- Primary human T cell isolation, activation, lentiviral transduction, and expansion.
- Multicolor flow cytometry: panel design, data acquisition (e.g., Attune/Novocyte/Cytek Aurora), and analysis (FlowJo).
- Molecular biology: PCR/qPCR, lentiviral packaging/titration, Western blot.
- Familiarity with Incucyte, MSD, and LDH release assay.
Preferred Skills/Experience
- PDX model development for CAR-T evaluation.
- Knowledge in a tumor disease area.
- Single-cell sequencing and data analysis/interpretation.
- Contributions to innovation (publications, patents, or conference presentations).
Benefits (per job posting)
- Medical/dental/vision; 401(k) with company match (vests day one).
- 8 weeks paid parental leave after 3 months.
- Paid time off (vacation, personal, sick, floating holidays) plus 11 company holidays.
- Base pay range: $110,706–$145,303 USD. Performance-based bonus and/or equity available in eligible roles.
Scientist to join an interdisciplinary cell therapy team advancing CAR-T cell therapies for solid tumors; central to the in vivo CAR-T platform and will drive preclinical development from construct design through animal model efficacy studies.
Key Responsibilities
- Design and execute in vitro functional assays.
- Perform binder selection for CAR design.
- Handle and engineer human and murine T cells.
- Engineer and maintain cancer cell lines for model development.
- Analyze and interpret data, troubleshoot, and present/engage internal stakeholders.
- Maintain detailed experimental records; contribute to scientific reports, presentations, and patent documentation.
Requirements
- PhD in Immunology, Immuno-Oncology, Tumor Immunology, Cancer Biology, or closely related field.
- Up to 3 years postdoctoral experience (PhD completed within past 3 years strongly encouraged).
- Primary human T cell isolation, activation, lentiviral transduction, and expansion.
- Multicolor flow cytometry: panel design, data acquisition (e.g., Attune/Novocyte/Cytek Aurora), and analysis (FlowJo).
- Molecular biology: PCR/qPCR, lentiviral packaging/titration, Western blot.
- Familiarity with Incucyte, MSD, and LDH release assay.
Preferred Skills/Experience
- PDX model development for CAR-T evaluation.
- Knowledge in a tumor disease area.
- Single-cell sequencing and data analysis/interpretation.
- Contributions to innovation (publications, patents, or conference presentations).
Benefits (per job posting)
- Medical/dental/vision; 401(k) with company match (vests day one).
- 8 weeks paid parental leave after 3 months.
- Paid time off (vacation, personal, sick, floating holidays) plus 11 company holidays.
- Base pay range: $110,706–$145,303 USD. Performance-based bonus and/or equity available in eligible roles.