Scientist, Solid Tumor CAR-T

Role: Scientist, Solid Tumor CAR-T at Legend Biotech, focusing on preclinical development of CAR-T therapies for solid tumors. Responsibilities include designing in vitro functional assays, T cell engineering, binder selection for CAR constructs, cell line development, data analysis, troubleshooting, and contributing to scientific reports and patent documentation. The role supports advancing in vivo CAR-T platforms from construct design to efficacy studies. Requirements: PhD in Immunology, Immuno-Oncology, or related fields, with up to 3 years postdoctoral experience; expertise in primary human T cell isolation, activation, lentiviral transduction, flow cytometry (Attune, Cytek Aurora), molecular biology techniques, and familiarity with in vivo models such as PDX. Preferred skills include experience with single-cell sequencing, tumor-specific models, and contributions to innovation (publications/patents). The position is based in Philadelphia, PA, and involves working within a collaborative, fast-paced environment dedicated to cell therapy for oncology, specifically multiple myeloma. High-value aspects include cell therapy modalities (CAR-T), early to mid-stage preclinical research, and a focus on solid tumor targets. The role reports to R&D leadership and emphasizes technical excellence and scientific innovation.