Scientist, Rare Disease Biology
Amgen
September 10, 2026
Full-time
Remote friendly (Thousand Oaks, CA)
Worldwide
Clinical Research and Development
Role: Rare Disease Biology Scientist focused on discovering and advancing therapies for rare diseases, particularly involving autoimmune and tissue remodeling mechanisms. Responsibilities: design and execute in vitro/ex vivo studies to investigate disease pathways such as immune dysregulation and fibroblast activation; generate data supporting target validation and program progression; integrate experimental, genetic, and clinical data to develop mechanistic insights; contribute to innovative assay development; collaborate with multidisciplinary teams and external partners; present findings internally. Requirements: PhD in Immunology, Cell Biology, or related field; or Master's with 2+ years or Bachelor's with 4+ years research experience. Preferred skills include expertise in fibroblast biology, tissue remodeling, cellular assay design, and advanced data analysis with transcriptomic or proteomic approaches; experience working with primary human tissues and advanced in vitro models; familiarity with AI-driven tools is advantageous. High-Value: focus on autoimmune diseases like Thyroid Eye Disease, tissue remodeling, fibrosis, and inflammatory pathways; experience in translational research and complex biological data interpretation. Work Setup: not specified, likely research laboratory environment; no travel requirements stated.