Scientist, Purification, RNA Process Development

Role: RNA Process Development Scientist focused on designing and optimizing purification processes for drug substance programs across circular and linear mRNA modalities. Responsibilities: conduct experiments using DoE and statistical tools to define critical process parameters, collaborate with analytical and upstream teams for characterization and yield optimization, prepare technical reports, and support tech transfer to GMP manufacturing. Qualifications: Bachelor's with 6+ years, Master's with 4-6 years, or PhD with up to 2 years in Bio/Chemical Engineering, Chemistry, or related fields. Expertise in chromatography, filtration (TFF/UF-DF), statistical experimental design, and biophysical analytical techniques like HPLC, CE, gel electrophoresis. Knowledge of cGMP, ICH, and QbD principles applicable to clinical manufacturing is required. Preferred: familiarity with nucleic acid and lipid chemistry, scale-down and mechanistic modeling. High-Value: focus on nucleic acid therapeutics, early to late-stage development, process optimization, and GMP tech transfer. Work setup: location unspecified; expected to support manufacturing activities.