Scientist, Protein Analytics, Discovery Biologics

Role Summary

Scientist, Protein Analytics, Discovery Biologics — On-site, full-time in Boston. Focused on characterization of protein-based therapeutics and supporting discovery and early development programs within the Discovery Biologics group.

Responsibilities

• Contribute to the Discovery Biologics pipeline by generating high quality data for protein characterization including antigens, antibodies, and other fusion proteins.
• Perform routine and advanced protein characterization using techniques such as HPLC/UPLC (SEC, IEX, RP), Capillary electrophoresis (CE-SDS, cIEF), LC-MS.
• Interpret and present analytical data to cross-functional teams.
• Collaborate with protein engineering, purification, and formulation teams to support candidate selection and optimization.
• Follow and author technical reports, SOPs, and contribute to regulatory documentation as needed.
• Maintain accurate and organized laboratory records in compliance with internal quality standards.
• Serve as a functional area representative on program teams.
• Generate frequent characterization summary reports.
• Troubleshoot automation methods and devices to maintain high throughput protein analyses.

Qualifications

• Minimum: Bachelor‚Äôs in a relevant field (protein sciences, biophysics, chemical or bioengineering, biochemistry, or related life sciences) with 2 years of hands-on industry experience; or Master‚Äôs in Biochemistry or related discipline with 0‚Äì1 years of experience.
• Hands-on experience with protein analytical techniques, especially chromatography-based methods.
• Familiarity with protein structure, post-translational modifications, glycosylation.
• Excellent problem-solving skills and ability to work independently and collaboratively in a fast-paced environment.
• Familiarity with biophysical techniques (SEC; HIC, DSF, DSC) and their data management.
• Familiarity with LC-MS workflows and sample preparation.
• Ability to multitask, manage time, and prioritize activities.
• Excellent attention to detail and record keeping in electronic lab notebooks.
• Excellent communication and collaboration skills.

Skills

• Automated Liquid Handling Systems
• Biochemistry
• Biophysical Characterization
• Capillary Electrophoresis (CE)
• High-Performance Liquid Chromatography (HPLC)
• Liquid Chromatography-Mass Spectrometry (LC-MS)
• Protein Analysis, Protein Characterization
• Protein Expression, Protein Purifications
• Size Exclusion Chromatography (SEC)
• Ultra Performance Liquid Chromatography (UPLC)
• Empower Software (preferred)
• Functional Assays (preferred)
• Surface Plasmon Resonance (SPR) (preferred)

Education

• B.S. in a relevant field (e.g., protein sciences, biophysics, chemical or bioengineering, biochemistry) with 2 years of industry experience, or Master‚Äôs in Biochemistry or related discipline with 0‚Äì1 years of experience.