Scientist – Preclinical Team

Responsibilities

• Partner with the Principal Scientist and Director to provide preclinical expertise, including animal handling and study design.
• Plan, execute, and analyze in vivo and ex vivo studies to support program objectives.
• Perform cell-based assays and tissue analyses from in vivo studies; compile and report results.
• Conduct survival surgeries and establish rodent models using aseptic techniques.
• Develop, characterize, and implement new animal models to enhance pharmacology study effectiveness.
• Maintain detailed, audit-ready documentation of all studies to ensure data integrity and traceability.
• Optimize and implement best practices for in vivo research, including model selection, dosing strategies, and sample/data collection techniques.
• Ensure compliance with regulatory guidelines and ethical standards for all preclinical activities.
• Evaluate and integrate new technologies and platforms to improve study efficiency and quality.
• Perform and interpret preclinical imaging studies (e.g., IVIS).
• Contribute to a team culture that promotes continuous improvement, ownership, and inclusion.

Requirements

• Ph.D. in a relevant scientific discipline with expertise in nonclinical operations within drug discovery and development.
• Hands-on experience with cell biology techniques, including RNA/DNA extraction, PCR, Western blot, ELISA, and interventional assays for small molecules and biologics.

Preferred Qualifications

• Experience across diverse therapeutic modalities (small molecules, biologics, nucleic acid therapeutics, gene therapy).
• Familiarity with age-related disease models (inflammation, metabolic disorders, neurodegeneration, muscle atrophy, bone/joint deficits).
• Experience with metabolic chambers, behavioral assays, and related data analysis.

Work Environment and Physical Demands

• On-site laboratory environment with routine handling of animals and biological samples.
• Prolonged periods of standing and performing surgical or technical procedures.
• Ability to lift laboratory materials up to 20 pounds.