Scientist, Oncology TCR-T Cell Therapy

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person. AstraZeneca is a global, innovation-driven biopharmaceutical business that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. But we are more than one of the world's leading pharmaceutical companies.

We are seeking a highly motivated and independent Scientist to join our rapidly growing Cell Therapy Team. In this role, you will contribute to advancing innovative Cell Therapy products by designing and conducting laboratory experiments, developing methodology, and generating and interpreting scientific data in a highly collaborative environment. Expertise in in vitro and in vivo studies and T cell biology is critical for this role. To be successful in this role, you must be well-organized and keep an excellent written record of your work. You will be based in Gaithersburg, MD and report to the Associate Director, TCR-T Cell Therapy.

Accountabilities

• Conducts hands-on in vivo research
• Conducts routine in vitro experiments
• Contributes to the plans and designs of in vitro and in vivo studies
• Communicates the results to team members and is involved in the interpretation of data
• Supports a team and works collaboratively with project managers to ensure the efficient relay of information and forward translation of data
  
  

Education

• Bachelor's degree in Immunology, Cancer Biology, Cell Biology, or relevant scientific field with 3+ years of research experience or Master’s degree with at least 1 year of experience.
  
  

Essential Skills

• In vivo skillset including animal handling, mouse tumor models, standard routes of dosing and engraftment
• Proficiency in cell culture of established cell lines and primary human immune cells
• Hands-on expertise in T-cell functional characterization assays, including in vitro cytotoxicity, proliferation, and cytokine measurement
• Experience in the execution and analyses of flow cytometry experiments
• Problem-solving skills related to research and data analysis
  
  

Preferred Qualifications

• Ability to lead a small in vitro and in vivo science project
• Transfection/transduction and expansion of primary cells
• Basic experience in developing cellular therapies, including CAR-T/CAR-NK, TCR-T therapies, and/or TIL therapies.
• CRISPR/genome editing experience
• Biotechnology or pharmaceutical industry experience preferred
  
  

#CellTherapy

The annual base pay for this position ranges from $87,000 to $130,000. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program. Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Date Posted

19-Sep-2025

Closing Date

26-Sep-2025

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.