Scientist, Oligonucleotide Synthesis
GSK
August 08, 2026
On-site
Cambridge, MA
Operations
Position Summary:
Help establish pre-clinical capabilities within GSK’s growing oligonucleotide synthesis lab for SPOS of modalities including ASOs, siRNA, SSO, and RNA editors screening; high-throughput automation, conjugates, and method development.
Role Responsibilities:
- Support pre-clinical oligonucleotide high-throughput and mid-scale synthesis of ASOs, siRNA, SSO, and RNA editors using routine and novel next-generation amidite chemistries.
- Perform hands-on work and maintain high-throughput automation workflows for routine and next-generation chemistry and oligo method development.
- Maintain SOPs for synthesis, processing, and purification to ensure high-quality, reproducible results.
- Collaborate with oligo analytical and delivery chemistry teams to ensure excellence in oligonucleotide and conjugate synthesis.
- Collaborate with various teams to achieve synthetic project goals.
Qualifications:
- MS with 2+ years or BS with 4+ years in chemistry, chemical biology, or related field.
- Direct experience with laboratory automation platforms (e.g., Lynx from Dynamic Devices, Fluent from Tecan, or similar).
- Familiarity with Mermade 192X, Dr. Oligo 192 XLc, or other high-throughput synthesizers; LC/HRMS, UPHLC, LC/MS analytics.
- Proficiency in oligonucleotide synthesis (SPOS) and biological understanding of RNA therapeutics (ASO, siRNA, SSO, RNA editors).
Preferred:
- MS with 2+ years or more in oligonucleotide synthesis and/or related chemistry.
- Team-focused; initiative to troubleshoot and implement solutions.
- Strong written/verbal communication, attention to detail, organization, and collaboration.
- Experience with oligonucleotide conjugation chemistries (desirable).
- Strong urgency, flexibility, independence, accountability, and integrity.
Working Arrangement:
On-site role in Cambridge, MA lab; regular lab work required; no hybrid/remote.
Application Instructions:
Apply and tell GSK about your lab experience and contributions you want to make.
Help establish pre-clinical capabilities within GSK’s growing oligonucleotide synthesis lab for SPOS of modalities including ASOs, siRNA, SSO, and RNA editors screening; high-throughput automation, conjugates, and method development.
Role Responsibilities:
- Support pre-clinical oligonucleotide high-throughput and mid-scale synthesis of ASOs, siRNA, SSO, and RNA editors using routine and novel next-generation amidite chemistries.
- Perform hands-on work and maintain high-throughput automation workflows for routine and next-generation chemistry and oligo method development.
- Maintain SOPs for synthesis, processing, and purification to ensure high-quality, reproducible results.
- Collaborate with oligo analytical and delivery chemistry teams to ensure excellence in oligonucleotide and conjugate synthesis.
- Collaborate with various teams to achieve synthetic project goals.
Qualifications:
- MS with 2+ years or BS with 4+ years in chemistry, chemical biology, or related field.
- Direct experience with laboratory automation platforms (e.g., Lynx from Dynamic Devices, Fluent from Tecan, or similar).
- Familiarity with Mermade 192X, Dr. Oligo 192 XLc, or other high-throughput synthesizers; LC/HRMS, UPHLC, LC/MS analytics.
- Proficiency in oligonucleotide synthesis (SPOS) and biological understanding of RNA therapeutics (ASO, siRNA, SSO, RNA editors).
Preferred:
- MS with 2+ years or more in oligonucleotide synthesis and/or related chemistry.
- Team-focused; initiative to troubleshoot and implement solutions.
- Strong written/verbal communication, attention to detail, organization, and collaboration.
- Experience with oligonucleotide conjugation chemistries (desirable).
- Strong urgency, flexibility, independence, accountability, and integrity.
Working Arrangement:
On-site role in Cambridge, MA lab; regular lab work required; no hybrid/remote.
Application Instructions:
Apply and tell GSK about your lab experience and contributions you want to make.