Scientist, Oligonucleotide Analytical Development

Role Summary

This role conducts oligonucleotide analytical development to support the Oligonucleotide Transport Vehicle (OTV) platform, contributing to programs as the therapeutics move toward the clinical phase.

Responsibilities

• Design, execute, and interpret stability-indicating chromatographic methods for ASOs/siRNA.
• Develop and apply complementary characterization techniques for ASOs/siRNA, including UV–Vis spectroscopy, mass spectrometry, NMR, Karl Fischer titration, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and circular dichroism (CD).
• Analyze and interpret results, leveraging knowledge of oligonucleotide synthesis and purification processes to understand impurity profiles.
• Transfer analytical methods and manage activities at partner CDMOs, as needed (travel may be required).
• Author and/or review analytical data, specifications, Certificates of Analysis, and method validation protocols and reports.
• Collaborate with discovery scientists, process chemists, quality, and project teams to advance our portfolio and analytical strategies and ensure timely flow of information.
• Experience with modern artificial intelligence or machine-learning approaches to support chemistry workflows is a plus.
• Perform other responsibilities as needed.

Qualifications

• Required: M.Sc./B.Sc. with 5+ years of relevant experience, with a track record of leadership and innovation demonstrated by publications and/or patents.
• Required: Deep understanding and excellence in the analysis of oligonucleotides and their starting materials.
• Required: Expertise in mass spectrometry.
• Required: Knowledge of phase-appropriate QC/analytics relevant to oligonucleotide analysis.
• Required: Strong written and verbal communication skills.

Skills

• Mass spectrometry
• Oligonucleotide analysis and starting materials
• Analytical method development and validation
• Data interpretation and scientific collaboration
• Communication and documentation

Additional Requirements

• Travel may be required for transferring methods and managing activities at partner CDMOs.