Scientist, Oligonucleotide Analytical Development

Role Summary

Scientist, Oligonucleotide Analytical Development responsible for carrying out oligonucleotide analytical development to support the Oligonucleotide Transport Vehicle (OTV) platform. Contribute to multiple programs as the OTV therapeutics enter clinical development. Collaborate with cross-functional teams to advance analytical strategies and ensure timely flow of information.

Responsibilities

• Design, execute, and interpret stability-indicating chromatographic methods for ASOs/siRNA.
• Develop and apply complementary characterization techniques for ASOs/siRNA, including UV–Vis spectroscopy, mass spectrometry, NMR, Karl Fischer titration, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and circular dichroism (CD).
• Analyze and interpret results, leveraging knowledge of oligonucleotide synthesis and purification processes to understand impurity profiles.
• Transfer analytical methods and manage activities at partner CDMOs, as needed (travel may be required).
• Author and/or review analytical data, specifications, Certificates of Analysis, and method validation protocols and reports.
• Collaborate with discovery scientists, process chemists, quality, and project teams to advance our portfolio and analytical strategies and ensure timely flow of information.
• Experience with modern artificial intelligence or machine-learning approaches to support chemistry workflows is a plus.
• Perform other responsibilities as needed.

Qualifications

• M.Sc./B.Sc. with 5+ years of relevant experience, with a record of scientific leadership and innovation as demonstrated by publications and/or patents
• Deep understanding of and demonstrated excellence in the analysis of oligonucleotides and their starting materials.
• Expertise in mass spectrometry is expected
• Knowledge of phase-appropriate QC/analytics relevant to oligonucleotide analysis
• Strong written and verbal communication skills