Scientist, Non-Viral Gene Editing Platforms
Bristol Myers Squibb
6 months ago
On-site
Seattle, WA
Clinical Research and Development
Position Responsibilities:
- Spend the majority of time working in the lab independently executing experiments and recording detailed ELN entries
- Optimize base ex vivo editing platform and implement new technologies for continuous improvement and next-gen in vivo platform development (e.g., lipid nanoparticles)
- Routinely generate CAR-T cells including non-viral gene editing, expansion, and cryopreservation of engineered cells
- Thoroughly characterize engineered CAR-T cells including phenotypic analysis via flow cytometry, in vitro cytotoxicity assays (e.g., Incucyte), and genomic DNA extraction for downstream molecular analysis
- Independently analyze and interpret experimental data (experience with large and complex datasets a plus)
- Troubleshoot routine problems and initiatives related to continuous improvement or development of new approaches/technologies
- Proactively communicate and align with team members to achieve results and support cross-functional activities
- Generate key data to support decisions that impact the larger team
- Present findings in multidisciplinary meetings, logically explaining complex scientific concepts and clearly highlighting key messages
- May represent the department/team on program/project team or sub-team
Basic Qualifications:
- Bachelor’s degree with 5+ years of academic and/or industry experience
- OR Master’s degree with 3+ years of academic and/or industry experience
- OR Ph.D. (or equivalent advanced degree) in Life Sciences (no experience necessary)
Preferred Qualifications / Skills:
- Hands-on gene editing technology experience (CRISPR/Prime editing preferred)
- Experience with in vivo non-viral gene delivery platforms (including non-cell therapy applications)
- Strong molecular biology knowledge; DNA design tools (e.g., Benchling, Geneious)
- Experience culturing T cells (aseptic technique, T cell activation, primary cell culture maintenance)
- Multi-color flow cytometry (complex panel design, multi-parameter analysis using FlowJo)
- Ability to multi-task, independently organize time, develop timelines, and deliver results
- Thrive in a fast-paced, ever-changing environment; demonstrated teamwork
- Detail oriented; excellent verbal/written communication and careful documentation (prior ELN experience a plus)
Compensation (explicitly stated):
- Seattle, WA: $122,810 - $148,814 (full-time FTE). Additional incentive cash/stock may be available based on eligibility.
Benefits (explicitly stated):
- Health Coverage (medical, pharmacy, dental, vision)
- Wellbeing support programs (e.g., BMS Well-Being Account, BMS Living Life Better, EAP)
- Financial wellbeing and protection (e.g., 401(k), disability, life insurance, etc.)
- Paid Time Off (flexible time off and holiday/vacation details as stated; plus other eligibility-based time off)
Application instructions:
- If a role interests you but doesn’t perfectly match your resume, you are encouraged to apply anyway.
- Spend the majority of time working in the lab independently executing experiments and recording detailed ELN entries
- Optimize base ex vivo editing platform and implement new technologies for continuous improvement and next-gen in vivo platform development (e.g., lipid nanoparticles)
- Routinely generate CAR-T cells including non-viral gene editing, expansion, and cryopreservation of engineered cells
- Thoroughly characterize engineered CAR-T cells including phenotypic analysis via flow cytometry, in vitro cytotoxicity assays (e.g., Incucyte), and genomic DNA extraction for downstream molecular analysis
- Independently analyze and interpret experimental data (experience with large and complex datasets a plus)
- Troubleshoot routine problems and initiatives related to continuous improvement or development of new approaches/technologies
- Proactively communicate and align with team members to achieve results and support cross-functional activities
- Generate key data to support decisions that impact the larger team
- Present findings in multidisciplinary meetings, logically explaining complex scientific concepts and clearly highlighting key messages
- May represent the department/team on program/project team or sub-team
Basic Qualifications:
- Bachelor’s degree with 5+ years of academic and/or industry experience
- OR Master’s degree with 3+ years of academic and/or industry experience
- OR Ph.D. (or equivalent advanced degree) in Life Sciences (no experience necessary)
Preferred Qualifications / Skills:
- Hands-on gene editing technology experience (CRISPR/Prime editing preferred)
- Experience with in vivo non-viral gene delivery platforms (including non-cell therapy applications)
- Strong molecular biology knowledge; DNA design tools (e.g., Benchling, Geneious)
- Experience culturing T cells (aseptic technique, T cell activation, primary cell culture maintenance)
- Multi-color flow cytometry (complex panel design, multi-parameter analysis using FlowJo)
- Ability to multi-task, independently organize time, develop timelines, and deliver results
- Thrive in a fast-paced, ever-changing environment; demonstrated teamwork
- Detail oriented; excellent verbal/written communication and careful documentation (prior ELN experience a plus)
Compensation (explicitly stated):
- Seattle, WA: $122,810 - $148,814 (full-time FTE). Additional incentive cash/stock may be available based on eligibility.
Benefits (explicitly stated):
- Health Coverage (medical, pharmacy, dental, vision)
- Wellbeing support programs (e.g., BMS Well-Being Account, BMS Living Life Better, EAP)
- Financial wellbeing and protection (e.g., 401(k), disability, life insurance, etc.)
- Paid Time Off (flexible time off and holiday/vacation details as stated; plus other eligibility-based time off)
Application instructions:
- If a role interests you but doesn’t perfectly match your resume, you are encouraged to apply anyway.