Scientist - LC-MS/MS Bioanalytical
Amgen
June 26, 2026
On-site
Thousand Oaks, CA
Clinical Research and Development
Scientist LC-MS/MS Bioanalytical
What You Will Do
- Independently design, develop, validate, and implement quantitative LC-MS/MS bioanalytical methods for small molecules; perform bioanalysis for discovery, GLP preclinical, and regulated clinical studies.
- Critically review/interpret data; generate reports; manage projects; communicate results and presentations; support automation efforts; stay current with technology.
- Collaborate across R&D and contribute to key teams; may support publications, patents, and regulatory submissions. Peptide/protein quantitation by hybrid LC-MS/MS/MS and affinity capture is a plus.
Key Responsibilities
- Develop LC-MS/MS bioanalytical methods with quick turnaround; conduct small-molecule bioanalysis of parent/metabolites in plasma, urine, CSF, and tissues.
- Perform sample extraction (protein precipitation, SPE, LLE).
- Document in LIMS and electronic laboratory notebook systems.
- Ensure regulatory-compliant data for global submissions; author SOPs/methods/study reports/memos/regulatory documents.
- Communicate data to discovery/development teams; contribute to publications; present at meetings.
- Follow safety guidelines, training/SOP requirements; perform lab housekeeping.
Basic Qualifications
- PhD, PharmD, MD (with relevant post-doc where applicable), or MS + 3 years; or BS + 5 years in LC-MS/MS bioanalytical experience.
Preferred Qualifications
- Pharma/biotech experience; quantitative MS on triple quadrupole (QQQ); experience with varied matrices and SPE/LLE; automation/micro-sampling; GLP/GCP; regulated assay execution & method transfer; PK/TK understanding; fast-paced multi-project ability; problem-solving and project/time management; collaboration; supervisory/mentoring.
Benefits (Total Rewards Plan)
- Retirement/savings (company contributions), group medical/dental/vision, life & disability, flexible spending; annual bonus/incentives; stock-based long-term incentives; time-off; flexible work models where possible.
Application Instructions
- Apply now via careers.amgen.com.
What You Will Do
- Independently design, develop, validate, and implement quantitative LC-MS/MS bioanalytical methods for small molecules; perform bioanalysis for discovery, GLP preclinical, and regulated clinical studies.
- Critically review/interpret data; generate reports; manage projects; communicate results and presentations; support automation efforts; stay current with technology.
- Collaborate across R&D and contribute to key teams; may support publications, patents, and regulatory submissions. Peptide/protein quantitation by hybrid LC-MS/MS/MS and affinity capture is a plus.
Key Responsibilities
- Develop LC-MS/MS bioanalytical methods with quick turnaround; conduct small-molecule bioanalysis of parent/metabolites in plasma, urine, CSF, and tissues.
- Perform sample extraction (protein precipitation, SPE, LLE).
- Document in LIMS and electronic laboratory notebook systems.
- Ensure regulatory-compliant data for global submissions; author SOPs/methods/study reports/memos/regulatory documents.
- Communicate data to discovery/development teams; contribute to publications; present at meetings.
- Follow safety guidelines, training/SOP requirements; perform lab housekeeping.
Basic Qualifications
- PhD, PharmD, MD (with relevant post-doc where applicable), or MS + 3 years; or BS + 5 years in LC-MS/MS bioanalytical experience.
Preferred Qualifications
- Pharma/biotech experience; quantitative MS on triple quadrupole (QQQ); experience with varied matrices and SPE/LLE; automation/micro-sampling; GLP/GCP; regulated assay execution & method transfer; PK/TK understanding; fast-paced multi-project ability; problem-solving and project/time management; collaboration; supervisory/mentoring.
Benefits (Total Rewards Plan)
- Retirement/savings (company contributions), group medical/dental/vision, life & disability, flexible spending; annual bonus/incentives; stock-based long-term incentives; time-off; flexible work models where possible.
Application Instructions
- Apply now via careers.amgen.com.