Scientist, In Vivo CAR-T Pipeline
Legend Biotech
August 14, 2026
On-site
Philadelphia, PA
Clinical Research and Development
Role Overview:
Scientist to join the in vivo CAR-T development team, advancing the in vivo CAR-T platform from early discovery through preclinical development. Fully onsite, lab-based position in Philadelphia, PA.
Key Responsibilities:
- Design, plan, and execute experimental studies to advance cell and gene therapy platforms and pipeline programs.
- Conduct and analyze in vitro and in vivo studies to assess product potency, efficacy, and safety.
- Develop, optimize, and troubleshoot experimental assays, including:
- Cell line engineering
- Cell-based functional and cytotoxicity assays
- ELISA and PCR-based assays
- High-throughput binder screening
- Viral vector packaging and titration
- Analyze and interpret complex datasets; maintain accurate experimental documentation.
- Prepare reports and presentations and communicate findings to internal research and cross-functional teams.
Requirements:
- PhD in Immunology, Cell Biology, or Molecular; or Masterβs degree with 3β6+ years of relevant experience.
- Hands-on experience in immunology, cell therapy, gene therapy, or related fields.
- Viral vector systems experience (especially lentivirus) highly preferred.
- Industry or postdoctoral experience a plus.
Benefits and Paid Time Off (highlights):
- Medical, dental, vision; 401(k) match (vests day one)
- 8 weeks paid parental leave after 3 months
- Paid time off (vacation, personal, sick, floating holidays) and 11 company holidays
Pay Range (Base Pay): $96,267β$126,351 USD
Scientist to join the in vivo CAR-T development team, advancing the in vivo CAR-T platform from early discovery through preclinical development. Fully onsite, lab-based position in Philadelphia, PA.
Key Responsibilities:
- Design, plan, and execute experimental studies to advance cell and gene therapy platforms and pipeline programs.
- Conduct and analyze in vitro and in vivo studies to assess product potency, efficacy, and safety.
- Develop, optimize, and troubleshoot experimental assays, including:
- Cell line engineering
- Cell-based functional and cytotoxicity assays
- ELISA and PCR-based assays
- High-throughput binder screening
- Viral vector packaging and titration
- Analyze and interpret complex datasets; maintain accurate experimental documentation.
- Prepare reports and presentations and communicate findings to internal research and cross-functional teams.
Requirements:
- PhD in Immunology, Cell Biology, or Molecular; or Masterβs degree with 3β6+ years of relevant experience.
- Hands-on experience in immunology, cell therapy, gene therapy, or related fields.
- Viral vector systems experience (especially lentivirus) highly preferred.
- Industry or postdoctoral experience a plus.
Benefits and Paid Time Off (highlights):
- Medical, dental, vision; 401(k) match (vests day one)
- 8 weeks paid parental leave after 3 months
- Paid time off (vacation, personal, sick, floating holidays) and 11 company holidays
Pay Range (Base Pay): $96,267β$126,351 USD