Scientist, In Vivo CAR-T
Legend Biotech
June 25, 2026
On-site
Somerset, NJ
Clinical Research and Development
Role Overview
- Support the in vivo CAR-T cell therapy program with hands-on work in lentiviral vector production and ex vivo/in vitro functional assays to evaluate product potency and safety.
- Collaborate across R&D teams to translate preclinical findings into clinical applications.
Key Responsibilities
- Develop and optimize cell-based assays for cell therapy programs.
- Perform immune cell isolation, activation, expansion, and T cell culture.
- Conduct lentiviral vector packaging, titration, and transduction experiments.
- Execute assays including multi-color flow cytometry, ELISA, cytotoxicity assays, and PCR.
- Design and carry out experiments (moderate independence), analyze and interpret data.
- Document results and present findings; collaborate cross-functionally to generate reproducible data.
- Support progression of research programs from discovery toward early development; maintain awareness of emerging technologies.
- Provide general lab support, participate in troubleshooting, and contribute to project execution.
Requirements
- PhD in Immunology/Cell Biology/Molecular Biology (or related).
- OR Master’s with 3–6+ years relevant experience.
- Hands-on experience in immunology, cell therapy/gene therapy (preferred: viral vector systems—especially lentivirus).
- Cell biology/molecular biology techniques; virology/viral vector systems (lentivirus); mammalian cell culture and immune cell handling.
- Flow cytometry and immunoassays.
- Strong data analysis, organization, problem-solving; ability to work independently and collaboratively.
Benefits (explicitly stated)
- Medical/dental/vision, 401(k) match (fully vested day one), 8 weeks paid parental leave after 3 months; PTO incl. vacation/personal/sick/floating holidays and 11 company holidays; other voluntary benefits.
Please note: Offered exclusively to permanent full-time employees (contractors not eligible).
- Support the in vivo CAR-T cell therapy program with hands-on work in lentiviral vector production and ex vivo/in vitro functional assays to evaluate product potency and safety.
- Collaborate across R&D teams to translate preclinical findings into clinical applications.
Key Responsibilities
- Develop and optimize cell-based assays for cell therapy programs.
- Perform immune cell isolation, activation, expansion, and T cell culture.
- Conduct lentiviral vector packaging, titration, and transduction experiments.
- Execute assays including multi-color flow cytometry, ELISA, cytotoxicity assays, and PCR.
- Design and carry out experiments (moderate independence), analyze and interpret data.
- Document results and present findings; collaborate cross-functionally to generate reproducible data.
- Support progression of research programs from discovery toward early development; maintain awareness of emerging technologies.
- Provide general lab support, participate in troubleshooting, and contribute to project execution.
Requirements
- PhD in Immunology/Cell Biology/Molecular Biology (or related).
- OR Master’s with 3–6+ years relevant experience.
- Hands-on experience in immunology, cell therapy/gene therapy (preferred: viral vector systems—especially lentivirus).
- Cell biology/molecular biology techniques; virology/viral vector systems (lentivirus); mammalian cell culture and immune cell handling.
- Flow cytometry and immunoassays.
- Strong data analysis, organization, problem-solving; ability to work independently and collaboratively.
Benefits (explicitly stated)
- Medical/dental/vision, 401(k) match (fully vested day one), 8 weeks paid parental leave after 3 months; PTO incl. vacation/personal/sick/floating holidays and 11 company holidays; other voluntary benefits.
Please note: Offered exclusively to permanent full-time employees (contractors not eligible).