Scientist III, Process Chemistry (Antibody-siRNA Conjugates)
Arrowhead Pharmaceuticals
August 30, 2026
Remote friendly (Madison, WI)
United States
Clinical Research and Development
Responsibilities:
- Optimize discovery-stage conjugation protocols for antibody-siRNA conjugates, improving yield, reproducibility, and product quality to enable scale-up.
- Develop GMP-ready, kilogram-scale conjugation processes, including site-specific and stochastic conjugation strategies, linker chemistry, and payload attachment.
- Hands-on laboratory work to design, execute, and optimize conjugation reactions, purification (chromatography, TFF/UF-DF), and analytical control strategies.
- Oversee and direct CROs/CDMOs executing process development and manufacturing; set technical direction, review data, and ensure timelines and quality.
- Characterize conjugates for DAR/siRNA-to-antibody ratio, aggregation, charge heterogeneity, and stability using methods such as HIC, SEC, IEX, LC-MS, and AEX.
- Lead technology transfer to internal/external manufacturing partners by authoring process descriptions, batch records, and development reports.
- Troubleshoot process and analytical challenges; design experiments to define parameters, ranges, and robustness for kilogram-scale operation.
- Collaborate cross-functionally with discovery chemistry, linker/conjugation chemistry, analytical development, and CMC teams.
Requirements:
- PhD in Organic Chemistry, Bioconjugate Chemistry, Chemical Engineering, or related field; or Bachelor’s/Master’s with commensurate hands-on industry experience.
- Demonstrated hands-on experience in siRNA conjugation development.
- Working knowledge of oligonucleotide and/or antibody chemistry, linker design, and bioconjugation methods.
- Familiarity with purification and analytical characterization of conjugates.
- Strong problem-solving, documentation, and communication skills.
Preferred:
- Experience with antibody-oligonucleotide conjugates (AOCs) or antibody-drug conjugates (ADCs).
- Experience scaling processes to GMP/kilogram scale and managing CRO/CDMO relationships.
- Knowledge of site-specific conjugation technologies (e.g., engineered cysteines, enzymatic/click chemistry).
- Experience with tech transfer and CMC/GMP environments.
Benefits/Compensation:
- Wisconsin pay range: $110,000–$125,000 USD.
- Competitive salaries and an excellent benefits package.
Application instructions:
- Candidates must have current, valid authorization to work in the country where this role is located.
- Optimize discovery-stage conjugation protocols for antibody-siRNA conjugates, improving yield, reproducibility, and product quality to enable scale-up.
- Develop GMP-ready, kilogram-scale conjugation processes, including site-specific and stochastic conjugation strategies, linker chemistry, and payload attachment.
- Hands-on laboratory work to design, execute, and optimize conjugation reactions, purification (chromatography, TFF/UF-DF), and analytical control strategies.
- Oversee and direct CROs/CDMOs executing process development and manufacturing; set technical direction, review data, and ensure timelines and quality.
- Characterize conjugates for DAR/siRNA-to-antibody ratio, aggregation, charge heterogeneity, and stability using methods such as HIC, SEC, IEX, LC-MS, and AEX.
- Lead technology transfer to internal/external manufacturing partners by authoring process descriptions, batch records, and development reports.
- Troubleshoot process and analytical challenges; design experiments to define parameters, ranges, and robustness for kilogram-scale operation.
- Collaborate cross-functionally with discovery chemistry, linker/conjugation chemistry, analytical development, and CMC teams.
Requirements:
- PhD in Organic Chemistry, Bioconjugate Chemistry, Chemical Engineering, or related field; or Bachelor’s/Master’s with commensurate hands-on industry experience.
- Demonstrated hands-on experience in siRNA conjugation development.
- Working knowledge of oligonucleotide and/or antibody chemistry, linker design, and bioconjugation methods.
- Familiarity with purification and analytical characterization of conjugates.
- Strong problem-solving, documentation, and communication skills.
Preferred:
- Experience with antibody-oligonucleotide conjugates (AOCs) or antibody-drug conjugates (ADCs).
- Experience scaling processes to GMP/kilogram scale and managing CRO/CDMO relationships.
- Knowledge of site-specific conjugation technologies (e.g., engineered cysteines, enzymatic/click chemistry).
- Experience with tech transfer and CMC/GMP environments.
Benefits/Compensation:
- Wisconsin pay range: $110,000–$125,000 USD.
- Competitive salaries and an excellent benefits package.
Application instructions:
- Candidates must have current, valid authorization to work in the country where this role is located.