Scientist III, Process Chemistry (Antibody-siRNA Conjugates)
Arrowhead Pharmaceuticals
June 26, 2026
On-site
Madison, WI
Clinical Research and Development
Responsibilities:
- Optimize discovery-stage conjugation protocols for antibody-siRNA conjugates to improve yield, reproducibility, and product quality.
- Develop GMP-ready, kilogram-scale conjugation processes, including site-specific and stochastic conjugation strategies, linker chemistry, and payload attachment.
- Perform hands-on conjugation reactions, purification (chromatography, TFF/UF-DF), and analytical control strategy development.
- Oversee CROs/CDMOs: set technical direction, review data, and ensure timelines and quality standards.
- Characterize conjugates for DAR/siRNA-to-antibody ratio, aggregation, charge heterogeneity, and stability (e.g., HIC, SEC, IEX, LC-MS, AEX).
- Lead technology transfer to internal/external manufacturing partners; author process descriptions, batch records, and development reports.
- Troubleshoot process/analytical issues; design experiments to define process parameters, ranges, and robustness for kilogram-scale operation.
- Collaborate cross-functionally with discovery chemistry, linker/conjugation chemistry, analytical development, and CMC teams.
Requirements:
- PhD in Organic Chemistry, Bioconjugate Chemistry, Chemical Engineering, or related field; or BS/MS with commensurate hands-on industry experience.
- Demonstrated hands-on experience in siRNA conjugation development.
- Working knowledge of oligonucleotide and/or antibody chemistry, linker design, and bioconjugation methods.
- Familiarity with purification and analytical characterization of conjugates.
- Strong problem-solving, documentation, and communication skills.
Preferred:
- Experience with AOCs or ADCs.
- Experience scaling processes to GMP/kilogram scale and managing CRO/CDMO relationships.
- Knowledge of site-specific conjugation technologies (e.g., engineered cysteines, enzymatic/click chemistry).
- Experience with tech transfer and CMC/GMP environments.
Benefits:
- Competitive salaries and an excellent benefit package.
Application instructions:
- Candidates must have current, valid authorization to work in the country where this role is located.
- Optimize discovery-stage conjugation protocols for antibody-siRNA conjugates to improve yield, reproducibility, and product quality.
- Develop GMP-ready, kilogram-scale conjugation processes, including site-specific and stochastic conjugation strategies, linker chemistry, and payload attachment.
- Perform hands-on conjugation reactions, purification (chromatography, TFF/UF-DF), and analytical control strategy development.
- Oversee CROs/CDMOs: set technical direction, review data, and ensure timelines and quality standards.
- Characterize conjugates for DAR/siRNA-to-antibody ratio, aggregation, charge heterogeneity, and stability (e.g., HIC, SEC, IEX, LC-MS, AEX).
- Lead technology transfer to internal/external manufacturing partners; author process descriptions, batch records, and development reports.
- Troubleshoot process/analytical issues; design experiments to define process parameters, ranges, and robustness for kilogram-scale operation.
- Collaborate cross-functionally with discovery chemistry, linker/conjugation chemistry, analytical development, and CMC teams.
Requirements:
- PhD in Organic Chemistry, Bioconjugate Chemistry, Chemical Engineering, or related field; or BS/MS with commensurate hands-on industry experience.
- Demonstrated hands-on experience in siRNA conjugation development.
- Working knowledge of oligonucleotide and/or antibody chemistry, linker design, and bioconjugation methods.
- Familiarity with purification and analytical characterization of conjugates.
- Strong problem-solving, documentation, and communication skills.
Preferred:
- Experience with AOCs or ADCs.
- Experience scaling processes to GMP/kilogram scale and managing CRO/CDMO relationships.
- Knowledge of site-specific conjugation technologies (e.g., engineered cysteines, enzymatic/click chemistry).
- Experience with tech transfer and CMC/GMP environments.
Benefits:
- Competitive salaries and an excellent benefit package.
Application instructions:
- Candidates must have current, valid authorization to work in the country where this role is located.