Scientist II, siRNA Screening Automation and Molecular Analytics

Role: Senior Scientist supporting high-throughput siRNA screening platform development within AbbVie's Biotherapeutic and Genetic Medicine (BGM) division. Primary objectives include developing and optimizing automation-enabled workflows for RNA-based assays to accelerate lead discovery and optimization across therapeutic areas. Responsibilities encompass executing automated siRNA screens, optimizing sample prep methods such as RNA extraction and RT-qPCR, designing experiments to assess siRNA activity, and establishing data analysis pipelines for large datasets, including NGS-based gene expression profiling. The role involves collaborating with cross-functional teams to enhance assay robustness, troubleshoot technical issues, and support platform buildout in a drug discovery setting. Qualifications: BS or MS in Molecular Biology, Genomics, Bioinformatics, or Bioengineering with 7+ years (BS) or 5+ years (MS) of industry experience, with strong hands-on expertise in laboratory automation, high-throughput workflows, RNA extraction, RT-qPCR, and NGS library prep. Experience supporting siRNA therapeutics, RNA biology, scripting, and data analysis tools is preferred. High-value specifics include focus on RNA-based assays, automation integration, NGS workflows, and support for early drug discovery in a fast-paced matrixed environment. The position reports to senior scientific leadership and involves cross-functional collaboration, with an emphasis on scientific communication and mentorship.