Scientist II, Oligonucleotides
BioMarin Pharmaceutical Inc.
August 31, 2026
On-site
San Rafael, CA
$121,800 - $167,530 USD yearly
Clinical Research and Development
Job Summary
Scientist II specializing in bioconjugation chemistry for nucleic acid-based therapeutics, designing and synthesizing bioconjugates including antibody-drug conjugates (ADCs), antibody-oligo conjugates (AOCs), and other complex biomolecules.
Key Responsibilities
- Engage in project team discussions; provide subject matter expertise and support methodology development.
- Collaborate with multidisciplinary teams (bioconjugation specialists, chemists, biologists) to drive project success.
- Design and synthesize bioconjugates (AOCs, peptide conjugates, and other complex biomolecules).
- Develop and optimize conjugation methodologies and purification processes.
- Characterize bioconjugates using HPLC, LC-MS, SDS-PAGE, and spectroscopy.
- Collaborate with Biology, Pharmacology, and Process Development for preclinical/clinical programs.
- Maintain accurate laboratory records and documentation.
- Present findings internally and at scientific meetings.
- Stay current with advancements in bioconjugation chemistry.
Qualifications
- Ph.D. in Chemistry, Biochemistry, or related field with focus on bioconjugation and organic synthesis.
- 3–5 years postdoctoral or industry experience in bioconjugation chemistry.
- Proven track record designing/synthesizing bioconjugates (AOCs, peptide conjugates).
- Strong knowledge of analytical techniques for bioconjugate characterization.
- Excellent problem-solving; ability to work independently and collaboratively.
- Strong written and verbal communication.
Benefits
- Health insurance, 401(k) matching, professional development opportunities.
Work Style
- Onsite daily role in San Rafael, CA; daily presence in research labs executing experiments.
Scientist II specializing in bioconjugation chemistry for nucleic acid-based therapeutics, designing and synthesizing bioconjugates including antibody-drug conjugates (ADCs), antibody-oligo conjugates (AOCs), and other complex biomolecules.
Key Responsibilities
- Engage in project team discussions; provide subject matter expertise and support methodology development.
- Collaborate with multidisciplinary teams (bioconjugation specialists, chemists, biologists) to drive project success.
- Design and synthesize bioconjugates (AOCs, peptide conjugates, and other complex biomolecules).
- Develop and optimize conjugation methodologies and purification processes.
- Characterize bioconjugates using HPLC, LC-MS, SDS-PAGE, and spectroscopy.
- Collaborate with Biology, Pharmacology, and Process Development for preclinical/clinical programs.
- Maintain accurate laboratory records and documentation.
- Present findings internally and at scientific meetings.
- Stay current with advancements in bioconjugation chemistry.
Qualifications
- Ph.D. in Chemistry, Biochemistry, or related field with focus on bioconjugation and organic synthesis.
- 3–5 years postdoctoral or industry experience in bioconjugation chemistry.
- Proven track record designing/synthesizing bioconjugates (AOCs, peptide conjugates).
- Strong knowledge of analytical techniques for bioconjugate characterization.
- Excellent problem-solving; ability to work independently and collaboratively.
- Strong written and verbal communication.
Benefits
- Health insurance, 401(k) matching, professional development opportunities.
Work Style
- Onsite daily role in San Rafael, CA; daily presence in research labs executing experiments.