Scientist II, In Vivo, Enzymatic and Metabolic Therapeutic Area

Role Summary

We are seeking a motivated Scientist with experience in genetic metabolic diseases to join the Enzymatic and Metabolic In Vivo team. The Scientist will design and execute key in vivo studies to develop therapeutics for genetic metabolic disorders, collaborating across the Research and Early Development organization to identify and pursue in vivo strategies. The role emphasizes in vivo study design, animal model development, and the application of in vivo methods and techniques, with a focus on enzymatic and metabolic biology.

Responsibilities

• Research Support
• Conduct research on genetic metabolic diseases
• Contribute to novel therapeutic programs based on innovative discoveries that could lead to new, high-impact opportunities for patients
• Perform research and publish findings in high-impact journals and present research at major conferences
• Effectively partner with other scientists and the Research and Early Development team to develop and execute on the program's strategic plan
• Present program data at a range of internal forums, including project team meetings, Research Department Seminars and Research leadership governance forums
• Write, review and contribute to study synopses, protocols, study reports and regulatory documents
• Collaborate with various BioMarin functions, CROs, university or analytical laboratories, business partners, as necessary to ensure appropriate/timely progression of projects
• Participate in multi-disciplinary drug development teams and may lead sub-teams
• Excellent written and verbal communication
• Ability to build/foster productive cross-functional collaborations both within and external to BioMarin
• Execute hands-on responsibilities including but not limited to animal handling and restraint (rodents), administration via various routes of administration, including intravenous (tail-vein), in-life animal health monitoring and measurements, clinical observations, sample collection and processing, and accurate data collection
• Providing daily care and monitoring of mice or rats, including health checks and documentation, as required
• Follow all institutional, local, and federal regulations regarding animal care and use; adhere to safety protocols and maintain a clean and organized work environment; maintain detailed and accurate records
• Communicate experimental plans and results to the project team; support product development and regulatory filings for pivotal clinical studies
• Work independently to effectively manage time and prioritize tasks to meet deadlines
• Share knowledge with other team members
• Document experimental methods and outcomes using Electronic Lab Notebooks and maintain technical SOPs
• Other duties as assigned
• Willingness to work on site full time including off hours and weekends based on study needs

Qualifications

• Demonstrated experience in metabolic biology/disease research in academia or industry (preferred) including publication record
• Strong analytical, problem-solving, and decision-making skills
• Strong understanding of genetically engineered models, breeding and management, and gene therapy modalities
• Excellent oral and written communication skills
• Passion for contributing scientific skills to develop therapies for patients in need
• Proficiency with computer databases for analysis and data entry
• Ability to work under time constraints with minimal day-to-day direction and in multidisciplinary teams
• Ability to work with external regulatory agencies and accreditation groups
• Some off-core business hours work may be required
• Complete all company training requirements
• Follow safety standards and wear required PPE; maintain occupational health practices
• This position is on-site and considered a critical resource

Education

• PhD in a related subject area with demonstrated in vivo research experience in metabolic disease
• Postdoctoral or industry (2-5 years preferred) experience in genetic metabolic diseases
• Extensive hands-on experience with rodent in vivo work in the metabolic field

Additional Requirements

• This position is full-time on-site and based in Petaluma, CA with occasional work on site in San Rafael, CA
• Note: This description describes the general nature of the job and may include other duties as assigned