Scientist II, In-Vitro & Nonclinical Assay Development
Tonix Pharmaceuticals
August 21, 2026
Remote friendly (Frederick, MD)
United States
Clinical Research and Development
Job Summary
Scientist II will support Tonix Pharmaceuticals’ preclinical research programs through the development, optimization, and execution of in vitro and nonclinical assays. The role contributes to translational research using cell-based assays, DMPK/ADME assays, 3D cell culture and organoid systems, and other nonclinical models to evaluate therapeutic candidates.
Essential Functions
- Develop, optimize, and execute in vitro cell-based and biochemical assays.
- Perform and support DMPK/ADME assays (permeability, protein binding, metabolic/CYP-related assays, cytotoxicity, and other screening assays).
- Develop and evaluate 3D cell culture, spheroid, and organoid-based assay systems.
- Support nonclinical assays/models to evaluate efficacy, pharmacology, safety, and mechanism of action.
- Design experiments; develop/optimize protocols; analyze and troubleshoot assays; document results.
- Maintain mammalian cell culture systems (cell lines, primary/specialized systems).
- Apply molecular, biochemical, imaging, and viability-based methods (RT-PCR, Western blotting, ELISA, luminescence assays, microscopy, etc.).
- Collaborate with internal scientists and external partners/CROs.
- Prepare data summaries, presentations, protocols, reports.
- Maintain accurate records and follow lab/quality/safety procedures.
Necessary/Preferred Skills
- Strong hands-on mammalian cell culture and in vitro assay development.
- Experience designing, optimizing, troubleshooting, and interpreting assays.
- DMPK/ADME familiarity preferred; 3D culture/organoid experience preferred.
- Proficiency in molecular/biochemical techniques and quantitative data analysis.
- Strong planning, problem-solving, technical writing, presentation, communication.
- Ability to work independently and in multidisciplinary teams.
Education/Experience
- Ph.D. (Pharmacology/Biochemistry/Biology/Biotechnology/Pharmaceutical Sciences or related) with 2+ years relevant experience, or M.S. with 4+ years.
- Relevant hands-on research experience in pharma/biotech/CRO/government/academia; in vitro pharmacology/DMPK/ADME/3D models/nonclinical work preferred.
Compensation & Benefits
- Medical, dental & vision; life/AD&D; short- and long-term disability; FSAs/HSAs; EAP; pet insurance; 401(k) with match and stock options; paid time off/sick time/paid holidays; career development/training.
Application Instructions
- No sponsorship; agency resumes not accepted unless contacted by internal Talent Acquisition.
Scientist II will support Tonix Pharmaceuticals’ preclinical research programs through the development, optimization, and execution of in vitro and nonclinical assays. The role contributes to translational research using cell-based assays, DMPK/ADME assays, 3D cell culture and organoid systems, and other nonclinical models to evaluate therapeutic candidates.
Essential Functions
- Develop, optimize, and execute in vitro cell-based and biochemical assays.
- Perform and support DMPK/ADME assays (permeability, protein binding, metabolic/CYP-related assays, cytotoxicity, and other screening assays).
- Develop and evaluate 3D cell culture, spheroid, and organoid-based assay systems.
- Support nonclinical assays/models to evaluate efficacy, pharmacology, safety, and mechanism of action.
- Design experiments; develop/optimize protocols; analyze and troubleshoot assays; document results.
- Maintain mammalian cell culture systems (cell lines, primary/specialized systems).
- Apply molecular, biochemical, imaging, and viability-based methods (RT-PCR, Western blotting, ELISA, luminescence assays, microscopy, etc.).
- Collaborate with internal scientists and external partners/CROs.
- Prepare data summaries, presentations, protocols, reports.
- Maintain accurate records and follow lab/quality/safety procedures.
Necessary/Preferred Skills
- Strong hands-on mammalian cell culture and in vitro assay development.
- Experience designing, optimizing, troubleshooting, and interpreting assays.
- DMPK/ADME familiarity preferred; 3D culture/organoid experience preferred.
- Proficiency in molecular/biochemical techniques and quantitative data analysis.
- Strong planning, problem-solving, technical writing, presentation, communication.
- Ability to work independently and in multidisciplinary teams.
Education/Experience
- Ph.D. (Pharmacology/Biochemistry/Biology/Biotechnology/Pharmaceutical Sciences or related) with 2+ years relevant experience, or M.S. with 4+ years.
- Relevant hands-on research experience in pharma/biotech/CRO/government/academia; in vitro pharmacology/DMPK/ADME/3D models/nonclinical work preferred.
Compensation & Benefits
- Medical, dental & vision; life/AD&D; short- and long-term disability; FSAs/HSAs; EAP; pet insurance; 401(k) with match and stock options; paid time off/sick time/paid holidays; career development/training.
Application Instructions
- No sponsorship; agency resumes not accepted unless contacted by internal Talent Acquisition.