Scientist II, Immunopharmacology - Peptide Discovery
AbbVie
9 hours ago
On-site
Worcester, MA
Clinical Research and Development
Responsibilities:
- Design, execute, and interpret immunological and pharmacological experiments to support IND-enabling and discovery-stage peptide therapeutic projects.
- Collect and analyze plasma and tissue exposure and receptor occupancy (RO) data to support dose–exposure–response predictions and inform oral dosing strategies.
- Perform in vivo immunology work with vivarium personnel, including adoptive transfer, rodent dosing (mice and rats), and tissue harvesting for immune response and target engagement analysis.
- Execute immunological assays (e.g., flow cytometry, ELISPOT, co-cultures, cytokine profiling, whole blood assays) to evaluate immune responses and peptide efficacy.
- Conduct molecular techniques including RNA isolation and qPCR/digital PCR for gene expression, cytokine, and biomarker assessment.
- Process lymphoid and barrier tissues (GI tract, skin, lymph nodes, spleen) for immune profiling and receptor occupancy/BioD assessment.
- Contribute data to BioD- and PK/PD-driven modeling efforts (e.g., immune cell targeting, dose saturation, target engagement across tissues).
- Refine experimental designs to address translational knowledge gaps and support clinical prediction models and regulatory packages.
- Interpret PK/PD data (plasma/tissue exposure and RO) to guide program decisions and optimize peptide candidates.
- Collaborate cross-functionally with teams such as DMPK, pharmacology, and chemistry to integrate findings into program objectives.
Qualifications:
- BS/MS (or equivalent) plus typically 7+ years (BS) or 5+ years (MS) of relevant industry experience in biology or related science.
- Proven ability to independently design, execute, and interpret complex immunology/pharmacology experiments.
- Hands-on expertise (preferred): ELISA, MSD, ELISPOT, flow cytometry, whole blood assays, qPCR/ddPCR, and RNA extraction/analysis.
- Required: experience with in vivo rodent procedures (dosing, tissue harvesting, adoptive transfer) in rats and/or mice.
- Familiarity with PK concepts (plasma/tissue exposure), receptor occupancy, and dose–exposure–response relationships; ability to collect, interpret, and communicate relevant data.
- Ability to learn and implement new experimental techniques; strong organizational, multitasking, and time-management skills.
- Excellent scientific writing and verbal communication skills.
- Collaborative mindset across multidisciplinary teams (e.g., DMPK, pharmacology, clinical sciences).
Benefits (if explicitly stated):
- Paid time off (vacation, holidays, sick), medical/dental/vision insurance, 401(k) (eligible employees), and short-term incentive program eligibility.
- Design, execute, and interpret immunological and pharmacological experiments to support IND-enabling and discovery-stage peptide therapeutic projects.
- Collect and analyze plasma and tissue exposure and receptor occupancy (RO) data to support dose–exposure–response predictions and inform oral dosing strategies.
- Perform in vivo immunology work with vivarium personnel, including adoptive transfer, rodent dosing (mice and rats), and tissue harvesting for immune response and target engagement analysis.
- Execute immunological assays (e.g., flow cytometry, ELISPOT, co-cultures, cytokine profiling, whole blood assays) to evaluate immune responses and peptide efficacy.
- Conduct molecular techniques including RNA isolation and qPCR/digital PCR for gene expression, cytokine, and biomarker assessment.
- Process lymphoid and barrier tissues (GI tract, skin, lymph nodes, spleen) for immune profiling and receptor occupancy/BioD assessment.
- Contribute data to BioD- and PK/PD-driven modeling efforts (e.g., immune cell targeting, dose saturation, target engagement across tissues).
- Refine experimental designs to address translational knowledge gaps and support clinical prediction models and regulatory packages.
- Interpret PK/PD data (plasma/tissue exposure and RO) to guide program decisions and optimize peptide candidates.
- Collaborate cross-functionally with teams such as DMPK, pharmacology, and chemistry to integrate findings into program objectives.
Qualifications:
- BS/MS (or equivalent) plus typically 7+ years (BS) or 5+ years (MS) of relevant industry experience in biology or related science.
- Proven ability to independently design, execute, and interpret complex immunology/pharmacology experiments.
- Hands-on expertise (preferred): ELISA, MSD, ELISPOT, flow cytometry, whole blood assays, qPCR/ddPCR, and RNA extraction/analysis.
- Required: experience with in vivo rodent procedures (dosing, tissue harvesting, adoptive transfer) in rats and/or mice.
- Familiarity with PK concepts (plasma/tissue exposure), receptor occupancy, and dose–exposure–response relationships; ability to collect, interpret, and communicate relevant data.
- Ability to learn and implement new experimental techniques; strong organizational, multitasking, and time-management skills.
- Excellent scientific writing and verbal communication skills.
- Collaborative mindset across multidisciplinary teams (e.g., DMPK, pharmacology, clinical sciences).
Benefits (if explicitly stated):
- Paid time off (vacation, holidays, sick), medical/dental/vision insurance, 401(k) (eligible employees), and short-term incentive program eligibility.