Scientist II, Degrader Antibody Conjugate Characterization
Nurix Therapeutics
August 07, 2026
Remote friendly (Brisbane, CA)
United States
Clinical Research and Development
Responsibilities:
- Design, execute, and own the DAC screening characterization platform, including DAR, aggregation, and protein quantitation; define QC thresholds to advance conjugates.
- Lead in-depth characterization of antibodies and advanced DACs, including positional isomers, glycosylation analysis, peptide mapping, and stability.
- Integrate DAR, purity, hydrophobicity, and stability data into unified assessments with QC cutoffs that drive go/no-go decisions; identify structure-quality trends across antibody, linker, and payload variables.
- Develop, optimize, and troubleshoot LCMS and HPLC methods for throughput and robustness; establish plate-based sample preparation workflows maintaining data quality at screening scale.
- Present findings to project and platform teams; collaborate with conjugation chemistry, bioanalytical, and cell screening groups to align workflows and influence advancement decisions.
Requirements:
- BS/BA with 12+ years, MS/MA with 8+ years, or PhD with 4+ years of industry experience in biochemistry, analytical chemistry, or related field.
- Expertise in ADC/DAC and antibody characterization from method development to data interpretation.
- Expertise with LCMS/HPLC for antibody/conjugate analysis (DAR, SEC, peptide mapping, HIC, and related methods).
- Direct industry experience characterizing ADCs with knowledge of conjugation chemistry, DAR heterogeneity, and common quality attributes.
- Track record of independently designing experiments, developing analytical methods, troubleshooting assays/instrumentation, and managing priorities across concurrent programs.
- Ability to synthesize complex analytical datasets into actionable conclusions and communicate clearly to cross-functional teams.
Preferred Qualifications:
- Native LCMS; positional isomer, glycan analysis; CE-SDS.
- Background in peptide mapping, biophysical binding assays, and thermal stability.
- Experience with developability assessment, forced degradation, or formulation-support analytics for biologics.
- Familiarity with Agilent instrumentation and analytical software (MassHunter, Byos, or equivalent).
- Design, execute, and own the DAC screening characterization platform, including DAR, aggregation, and protein quantitation; define QC thresholds to advance conjugates.
- Lead in-depth characterization of antibodies and advanced DACs, including positional isomers, glycosylation analysis, peptide mapping, and stability.
- Integrate DAR, purity, hydrophobicity, and stability data into unified assessments with QC cutoffs that drive go/no-go decisions; identify structure-quality trends across antibody, linker, and payload variables.
- Develop, optimize, and troubleshoot LCMS and HPLC methods for throughput and robustness; establish plate-based sample preparation workflows maintaining data quality at screening scale.
- Present findings to project and platform teams; collaborate with conjugation chemistry, bioanalytical, and cell screening groups to align workflows and influence advancement decisions.
Requirements:
- BS/BA with 12+ years, MS/MA with 8+ years, or PhD with 4+ years of industry experience in biochemistry, analytical chemistry, or related field.
- Expertise in ADC/DAC and antibody characterization from method development to data interpretation.
- Expertise with LCMS/HPLC for antibody/conjugate analysis (DAR, SEC, peptide mapping, HIC, and related methods).
- Direct industry experience characterizing ADCs with knowledge of conjugation chemistry, DAR heterogeneity, and common quality attributes.
- Track record of independently designing experiments, developing analytical methods, troubleshooting assays/instrumentation, and managing priorities across concurrent programs.
- Ability to synthesize complex analytical datasets into actionable conclusions and communicate clearly to cross-functional teams.
Preferred Qualifications:
- Native LCMS; positional isomer, glycan analysis; CE-SDS.
- Background in peptide mapping, biophysical binding assays, and thermal stability.
- Experience with developability assessment, forced degradation, or formulation-support analytics for biologics.
- Familiarity with Agilent instrumentation and analytical software (MassHunter, Byos, or equivalent).