Scientist II, Complex In Vitro Model
AbbVie
August 13, 2026
Remote friendly (Worcester, MA)
United States
$84,500 - $162,000 USD yearly
Clinical Research and Development
Key Responsibilities:
- Design and perform biochemical and cellular studies of drug potency and mechanism of action using primary human blood cells, cell lines, and complex in vitro systems such as organoids or organ-on-chip models.
- Analyze, interpret, and clearly communicate quantitative data.
- Conduct and organize activities and communicate through oral and written presentations.
- Read and apply relevant scientific literature.
- Maintain accurate and current records of research.
Qualifications:
- BS or MS in Biological science (Immunology, Biochemistry, Molecular Biology, Cell Biology, or related) with typically 7+ (BS) or 5+ (MS) years of relevant lab experience.
- Proficiency culturing primary human immune cells, immortalized cell lines, and organ/tissue cultures (including differentiated cells and iPSCs) using standard tissue culture and transwell systems.
- Experience developing and applying complex in vitro models (co-culture and advanced 3D cellular systems) to support discovery programs.
- Experience designing experiments for cell signaling, phosphoproteins, second messenger pathways, cell proliferation, gene reporter assays, and soluble mediator release.
- Expertise in ELISA/MSD, alphaLISA, HTRF, PCR, multicolor flow cytometry, high content microscopy, and related methodologies.
- Strong statistics background (e.g., Microsoft Excel and GraphPad Prism).
- Skilled in leveraging automation for assay robustness, throughput, and workflow miniaturization.
- Highly collaborative; strong organizational, communication, and interpersonal skills.
Benefits (if eligible/included in posting):
- Paid time off (vacation, holidays, sick), medical/dental/vision insurance, and 401(k); eligible for short-term incentive programs.
- Design and perform biochemical and cellular studies of drug potency and mechanism of action using primary human blood cells, cell lines, and complex in vitro systems such as organoids or organ-on-chip models.
- Analyze, interpret, and clearly communicate quantitative data.
- Conduct and organize activities and communicate through oral and written presentations.
- Read and apply relevant scientific literature.
- Maintain accurate and current records of research.
Qualifications:
- BS or MS in Biological science (Immunology, Biochemistry, Molecular Biology, Cell Biology, or related) with typically 7+ (BS) or 5+ (MS) years of relevant lab experience.
- Proficiency culturing primary human immune cells, immortalized cell lines, and organ/tissue cultures (including differentiated cells and iPSCs) using standard tissue culture and transwell systems.
- Experience developing and applying complex in vitro models (co-culture and advanced 3D cellular systems) to support discovery programs.
- Experience designing experiments for cell signaling, phosphoproteins, second messenger pathways, cell proliferation, gene reporter assays, and soluble mediator release.
- Expertise in ELISA/MSD, alphaLISA, HTRF, PCR, multicolor flow cytometry, high content microscopy, and related methodologies.
- Strong statistics background (e.g., Microsoft Excel and GraphPad Prism).
- Skilled in leveraging automation for assay robustness, throughput, and workflow miniaturization.
- Highly collaborative; strong organizational, communication, and interpersonal skills.
Benefits (if eligible/included in posting):
- Paid time off (vacation, holidays, sick), medical/dental/vision insurance, and 401(k); eligible for short-term incentive programs.