Scientist I, Radiopharmacology

Role Summary

Join our team to advance radiochemistry and cancer research, supporting the launch of our in vivo radio conjugate program. Support the operations and commercial teams for in vivo study planning and execution utilizing radio conjugates for testing in Champions extensive PDX Tumorbank in preclinical mouse pharmacology studies.

Responsibilities

• Design and execute radiolabeling reactions using a range of isotopes, including Lu-177, Ac-225, In-111, Zr-89, At-211, I-131, and Pb-212.
• Perform conjugation reactions between bifunctional chelators and peptides or proteins.
• Develop and optimize radiochemical synthesis protocols for both diagnostic and therapeutic applications.
• Conduct quality control and stability testing of radiolabeled products.
• Analyze experimental data, interpret results, and communicate findings to cross-functional teams.
• Support preclinical research studies, including biodistribution, pharmacokinetics, and dosimetry assessments.
• Prepare, review, and ensure compliance of study protocols and technical reports.
• Train and mentor junior staff in radiochemistry techniques, radiation safety, and handling of radioactive materials.
• Maintain accurate laboratory records.
• Stay current with advancements in radiochemistry, nuclear medicine, and isotope production technologies.
• Assist in the evaluation and implementation of new equipment, automation systems, and analytical tools.
• Other duties may be assigned verbally at any time.

Qualifications

• Knowledge, Skills, and Abilities: Expertise in radiochemistry, radiobiology, molecular imaging, and therapeutic radionuclide production and handling.
• Knowledge, Skills, and Abilities: Expertise in chromatography techniques such as TLC, column chromatography, and HPLC.
• Knowledge, Skills, and Abilities: Expertise in conducting in vivo studies using radiolabeled compounds.
• Knowledge, Skills, and Abilities: Experience with analysis and interpretation in vivo data of radioconjugate pharmaceuticals.

Education

• PhD in a relevant field (e.g., radiochemistry, chemistry, biochemistry, pharmaceutical sciences).
• Expertise in radiochemistry, radiobiology, molecular imaging, and therapeutic radionuclide production.
• Experience with analysis and interpretation in vivo data of radioconjugates.
• Strong computer, organizational, and multitasking skills.
• Excellent communication skills.

Additional Requirements

• Must be able to sit and use hands to finger, handle and feel.
• Must be able to lift and move packages weighing up to 50 pounds.
• Must be able to sit for long periods of time using a computer in a typical office environment in a multi-level facility.
• Some activities require repetitive motion and reaching, pulling, or pushing.
• In carrying out the duties of the job there will be frequent exposure to fumes and chemical hazards.
• Duties performed routinely require exposure to blood, body fluid and tissue.