Scientist I, Radiopharmacology

Role Summary

Scientist I, Radiopharmacology, based in Rockville, MD, reports to the Head of Radiopharmacology. The role advances radiochemistry and cancer research and supports the launch of the in vivo radioconjugate program. The incumbent will assist operations and commercial teams with in vivo study planning and execution, utilizing radioconjugates for testing in a comprehensive PDX tumor bank in preclinical mouse pharmacology studies.

Responsibilities

• Design and execute radiolabeling reactions using isotopes including Lu-177, Ac-225, In-111, Zr-89, At-211, I-131, and Pb-212.
• Perform conjugation reactions between bifunctional chelators and peptides or proteins.
• Develop and optimize radiochemical synthesis protocols for diagnostic and therapeutic applications.
• Conduct quality control and stability testing of radiolabeled compounds.
• Analyze experimental data, interpret results, and communicate findings to cross-functional teams.
• Support preclinical research studies, including biodistribution, pharmacokinetics, and dosimetry assessments.
• Prepare, review, and ensure compliance of study protocols and technical reports.
• Train and mentor junior staff in radiochemistry techniques, radiation safety, and handling of radioactive materials.
• Maintain accurate laboratory records.
• Stay current with advancements in radiochemistry, nuclear medicine, and isotope production technologies.
• Assist in the evaluation and implementation of new equipment, automation systems, and analytical tools.
• Other duties may be assigned verbally at any time.

Qualifications

• Expertise in radiochemistry, radiobiology, molecular imaging, and therapeutic radionuclide production and handling.
• Expertise in chromatography techniques such as thin-layer chromatography (TLC), column chromatography, and high-performance liquid chromatography (HPLC).
• Expertise in conducting in vivo studies using radiolabeled compounds.
• Experience with analysis and interpretation in vivo data of radioconjugate pharmaceuticals.

Education

• PhD in a relevant field (e.g., radiochemistry, chemistry, biochemistry, pharmaceutical sciences).

Additional Requirements

• Must be able to sit and use hands to finger, handle and feel.
• Must be able to lift and move packages weighing up to 50 pounds.
• Must be able to sit for long periods of time using a computer in a typical office environment in a multi-level facility.
• Some activities require repetitive motion and reaching, pulling, or pushing.
• In carrying out the duties of the job there will be frequent exposure to fumes and chemical hazards.
• Duties performed routinely require exposure to blood, body fluid and tissue.