Scientist I, Quality Control (2nd Shift)
Arrowhead Pharmaceuticals
August 25, 2026
On-site
Madison, WI
Operations
The Position: Scientist I, Quality Control (2nd shift; eligible for a 10% shift differential). Support analytical method validation, method transfer, and quality control testing for pharmaceutical raw materials, in-process manufacturing samples, drug substance, drug product, and stability studies.
Responsibilities:
- Perform analytical testing of raw materials, in-process samples, drug substances, drug products, and stability samples using validated methods.
- Execute method validation, method transfer, and routine QC testing per cGMP and ICH guidelines.
- Operate, troubleshoot, and interpret data from analytical instrumentation (LC-MS; HPLC/UHPLC—RP and AEX; GC; Karl Fischer titration; FTIR; Endotoxin/LAL; Raman spectroscopy).
- Analyze/interpret data, including stability trends and degradation profiles.
- Independently investigate analytical results; make sound scientific decisions ensuring data quality and compliance.
- Collaborate cross-functionally with Analytical Development, Manufacturing, and Quality.
- Lead technical discussions, troubleshoot analytical challenges, and contribute to continuous improvement.
- Train/mentor colleagues; maintain cGMP/GDP-compliant documentation.
- Support lab investigations, method improvements, and other QC initiatives.
Requirements:
- BS in Chemistry (or related) with 5+ years lab experience, or MS with 3+ years.
- cGMP and ICH laboratory requirements/operations knowledge.
- Strong documentation and attention to detail; able to work within hold times/turnaround targets.
- Experience testing oligonucleotides, peptides, or synthetic biomolecules.
- Hands-on experience with LCMS, AEX-HPLC, RP-HPLC/UHPLC, Karl Fischer titration, or LAL/endotoxin testing.
- Experience supporting in-process (real-time) testing in a manufacturing-adjacent QC lab.
- Proficient in analytical instrumentation, test methodology/validations/transfers, data acquisition systems, and cGMP policies/practices.
Pay range: $90,000 USD - $108,000 USD.
Application instructions: Candidates must have current, valid authorization to work in the country where the role is located.
Responsibilities:
- Perform analytical testing of raw materials, in-process samples, drug substances, drug products, and stability samples using validated methods.
- Execute method validation, method transfer, and routine QC testing per cGMP and ICH guidelines.
- Operate, troubleshoot, and interpret data from analytical instrumentation (LC-MS; HPLC/UHPLC—RP and AEX; GC; Karl Fischer titration; FTIR; Endotoxin/LAL; Raman spectroscopy).
- Analyze/interpret data, including stability trends and degradation profiles.
- Independently investigate analytical results; make sound scientific decisions ensuring data quality and compliance.
- Collaborate cross-functionally with Analytical Development, Manufacturing, and Quality.
- Lead technical discussions, troubleshoot analytical challenges, and contribute to continuous improvement.
- Train/mentor colleagues; maintain cGMP/GDP-compliant documentation.
- Support lab investigations, method improvements, and other QC initiatives.
Requirements:
- BS in Chemistry (or related) with 5+ years lab experience, or MS with 3+ years.
- cGMP and ICH laboratory requirements/operations knowledge.
- Strong documentation and attention to detail; able to work within hold times/turnaround targets.
- Experience testing oligonucleotides, peptides, or synthetic biomolecules.
- Hands-on experience with LCMS, AEX-HPLC, RP-HPLC/UHPLC, Karl Fischer titration, or LAL/endotoxin testing.
- Experience supporting in-process (real-time) testing in a manufacturing-adjacent QC lab.
- Proficient in analytical instrumentation, test methodology/validations/transfers, data acquisition systems, and cGMP policies/practices.
Pay range: $90,000 USD - $108,000 USD.
Application instructions: Candidates must have current, valid authorization to work in the country where the role is located.