Scientist I, Neuroscience

Role Summary

The Scientist I, Neuroscience is responsible for planning and performing scientific experiments that contribute to PTC’s research and drug discovery activities. The incumbent works cross-functionally with internal departments, and external resources as appropriate, as part of PTC’s discovery science project teams. The Scientist I, Neuroscience supports adherence to relevant regulatory requirements and company Standard Operating Procedures (SOPs) as appropriate.

Responsibilities

• With guidance from the advisor plans, initiates, directs and executes scientific research and experiments and interprets and communicates results as part of multi-disciplinary team(s). This includes performing analyses of primary research literature.
• Presents findings internally to cross-functional teams.
• May provide scientific advice to research leadership on projects and areas of expertise.
• Abides by all safety and regulatory guidelines.
• Maintains a detailed laboratory notebook.
• Performs other tasks as assigned
• Interviews and contributes to the evaluation of candidates.
• Abides by all safety requirements.
• May Participate in the development and writing of patent applications
• Contributes to general lab needs such as:
  • Equipment maintenance.
  • Capital equipment purchases.
  • Troubleshoot

Knowledge/Skills/Abilities Required

• Experience working with and/or establishing differentiated iPSCs is required.
• Excellent sterile technique and ability to establish and maintain various cell culture systems including primary and immortalized cell systems.
• Working knowledge of molecular biology (for example: RT-PCR, qPCR, RNAseq) and gene editing techniques required.
• Experience in protein quantification end analysis methods such as Western blot, ELISA, MSD
• Strong desire to work in a dynamic environment where innovation and initiative are expected.
• Minimum level of education and years of relevant work experience.
• Ph.D. in scientific discipline preferably in Neuroscience, Molecular Biology or Biochemistry with 1-2 years’ post-doctoral or Industry experience
• Special knowledge or skills needed and/or licenses or certificates required.
• Exercises independent judgement within defined procedures and practices.
• Demonstrates technical proficiency, collaboration with others within a fast-paced, matrixed, team environment consisting of internal and external team members.
• Possesses detailed and expert knowledge of scientific principles and concepts.
• Demonstrate ability to work effectively in a multi-disciplinary team environment.
• Ability to work independently and collaboratively, as required, in a fast-paced, matrixed, team environment consisting of internal and external team members.
• Demonstrate ability to work on complex problems to produce experimental data across one or more projects.
• Proficiency with Microsoft Office preferably MS Excel and MS PowerPoint or similar, and familiarity with basic statistical analytical methods
• Excellent verbal and written communication and skills.
• Analytical thinker with excellent problem-solving skills.
• Demonstrates an understanding of the strategic alignment of his/her work with corporate goal(s) and demonstrates the ability to adapt to changing priorities and deadlines.
• Excellent planning, organization and time management skills including the ability to support and prioritize multiple projects.
• Special knowledge or skills and/or licenses or certificates preferred.
• Experience designing and conducting cell-based studies of compound activity as well as mechanism of action studies.
• Travel requirements Up to 10%
• Office/Laboratory based position

Education

• Ph.D. in a scientific discipline (Neuroscience, Molecular Biology or Biochemistry) with 1-2 years’ post-doctoral or Industry experience preferred