Scientist I, Immunosafety

Role Summary

Evaluate immunosafety risk potential of candidate therapeutic large molecules using in vitro immunosafety assays to support development of preclinical molecules.

Responsibilities

• Execute human cytokine release assays including whole blood- and PBMC- based formats.
• Conduct complement activation assays, troubleshooting and optimizing as needed.
• Perform cell subset isolation protocols on human whole blood or PBMC samples.
• Conduct T cell proliferation assay using isolated cells.
• Analyze experimental data and maintain accurate documentation, placing data in proper scientific context through review of relevant literature and reporting findings at team meetings.

Qualifications

• B.S. in Biological Sciences, Cellular Immunology, or related field with typically 5 years of experience, or Master’s Degree or equivalent education with typically two years of experience.
• Understanding of cellular immunology with an emphasis on blood cell subsets and T cell biology.
• Experience with whole blood-based cell assays, blood cell isolation, and serum cytokine readouts.
• Experience with multicolor flow cytometry panel design, BD LSRFortessa instrument operation, BD FACSDive and FlowJo software, and flow cytometry data analysis.
• Excellent interpersonal and oral/written communication skills.
• Results-oriented work ethic and a positive "can-do" attitude with a strong sense of urgency and self-motivated desire to achieve common business goals.
• Demonstrated ability to collaborate effectively in a dynamic, cross-functional matrix environment.

Skills

• Multicolor flow cytometry panel design and data analysis
• BD LSRFortessa instrument operation
• BD FACSDive and FlowJo software
• Strong written and oral communication
• Cross-functional collaboration in matrix environments

Education

• B.S. in Biological Sciences, Cellular Immunology, or related field (or equivalent) with relevant experience; Master’s Degree preferred.