Scientist I/II, In Vivo Pharmacology
Nurix Therapeutics
6 months ago
On-site
Brisbane, CA
Clinical Research and Development
The position
- Lead efforts in inflammation using in vivo pharmacology and PK/PD.
- Conduct small-molecule PK/PD studies and characterize PK, PD, efficacy, and safety of therapeutic candidates.
- Use rodent models of inflammatory skin disease; establish new disease models in-house.
- Design and execute skin inflammation studies, including dosing and collection/processing of blood, skin, and lymphoid tissues.
- Support ex vivo/in vitro immunology and molecular assays.
- Perform immune cell profiling by flow cytometry and related biomarker work.
- (Scientist II) Oversee selected models/workflows, troubleshoot issues, implement technical improvements, and mentor junior staff.
Qualifications
- Ph.D. in pharmacology, cancer biology, immunology, or related field with relevant post-doctoral or industry experience; or B.S./M.S. in Pharmacology, Pharmaceutical Sciences, Biology, or related discipline.
- Experience requirements: Scientist I: typically ≥1 year (Ph.D.), ≥4 years (M.S.), or ≥8 years (B.S.); Scientist II: typically ≥4 years (Ph.D.), ≥8 years (M.S.), or ≥12 years (B.S.).
- Knowledge of PK/PD concepts and basic pharmacokinetic analysis.
- Strong hands-on skills: IV, PO, intradermal, and topical dosing; blood/tissue collection.
- Experience with inflammation/immunology/dermatology disease models (e.g., MC903/AD, imiquimod psoriasis, contact hypersensitivity, PCA, pruritus/itch, CIA, EAE) and clinical scoring.
- PD biomarker assessment experience (e.g., ELISA/multiplex cytokines, Western blot, flow cytometry, qPCR); multiparameter flow cytometry and ex vivo stimulation/cytokine release/proliferation assays preferred.
- Experience with electronic lab notebooks and data analysis/graphing software (e.g., Excel, Prism, FlowJo or similar).
- Excellent communication/presentation and interpersonal skills; ability to work in a dynamic, cross-functional environment.
- Lead efforts in inflammation using in vivo pharmacology and PK/PD.
- Conduct small-molecule PK/PD studies and characterize PK, PD, efficacy, and safety of therapeutic candidates.
- Use rodent models of inflammatory skin disease; establish new disease models in-house.
- Design and execute skin inflammation studies, including dosing and collection/processing of blood, skin, and lymphoid tissues.
- Support ex vivo/in vitro immunology and molecular assays.
- Perform immune cell profiling by flow cytometry and related biomarker work.
- (Scientist II) Oversee selected models/workflows, troubleshoot issues, implement technical improvements, and mentor junior staff.
Qualifications
- Ph.D. in pharmacology, cancer biology, immunology, or related field with relevant post-doctoral or industry experience; or B.S./M.S. in Pharmacology, Pharmaceutical Sciences, Biology, or related discipline.
- Experience requirements: Scientist I: typically ≥1 year (Ph.D.), ≥4 years (M.S.), or ≥8 years (B.S.); Scientist II: typically ≥4 years (Ph.D.), ≥8 years (M.S.), or ≥12 years (B.S.).
- Knowledge of PK/PD concepts and basic pharmacokinetic analysis.
- Strong hands-on skills: IV, PO, intradermal, and topical dosing; blood/tissue collection.
- Experience with inflammation/immunology/dermatology disease models (e.g., MC903/AD, imiquimod psoriasis, contact hypersensitivity, PCA, pruritus/itch, CIA, EAE) and clinical scoring.
- PD biomarker assessment experience (e.g., ELISA/multiplex cytokines, Western blot, flow cytometry, qPCR); multiparameter flow cytometry and ex vivo stimulation/cytokine release/proliferation assays preferred.
- Experience with electronic lab notebooks and data analysis/graphing software (e.g., Excel, Prism, FlowJo or similar).
- Excellent communication/presentation and interpersonal skills; ability to work in a dynamic, cross-functional environment.