Scientist I/II, CRISPR-X

Role Summary

Scientist I/II, CRISPR-X – Join a diverse, innovation-focused CRISPR-X team that pioneers novel gene editing therapies. The successful candidate will research, develop and advance the next generation of genome editing modalities and genetic therapies for a wide range of human indications, contributing enthusiasm, attention to detail, and a desire to create new medicines for patients.

Responsibilities

• Lead, design, and optimize research with the aims of exploring and developing next-generation gene editing strategies using CRISPR-based tools and beyond.
• Design, execute, and interpret research requiring molecular biology techniques including cloning, qPCR/ddPCR, NGS, RNA and DNA analysis, cell culture, and other cell-based assays.
• Analyze and present experimental data to a wide range of audiences.
• Dissect published literature to find novel solutions to gene editing problems.
• Generate, manage, evaluate, and maintain critical data in a highly organized manner, providing statistical analysis and troubleshooting where appropriate.

Qualifications

• Prior experience with gene editing, including applying and developing next generation gene editing technologies, such as prime editing, base editing, and recombinases and retrotransposons, in an academic and/or industry setting, with a track record demonstrating significant contributions.
• Ph.D. in biology, bioengineering, or related discipline.
• Scientist I – 0-3 years of professional experience
• Scientist II – 2-5 years of professional experience
• Outstanding problem-solving skills and attitude to think outside the box.
• Expertise in molecular biology, cell culture techniques and hepatocytes.
• Excellent writing, reviewing, and presentation skills.
• Challenges oneself continuously to enhance scientific capabilities.
• Ability to work independently as well as collaboratively in a results-oriented research team environment.
• Must possess critical thinking and self-reliance to solve tasks independently.
• Self-motivated and scientifically rigorous, with outstanding organization and multitasking capability
• Entrepreneurial spirit showing resourcefulness, accountability, agility to pivot, transparency, and productivity.

Preferred Qualifications

• Prior experience with protein and/or RNA engineering.
• Prior experience with diverse delivery technologies, including transfection/nucleofection, lipid nanoparticles, and viral vectors/particles.
• Prior experience with primary hepatocytes and high-throughput screening.

Skills

• Collaborative – Openness, One Team
• Undaunted – Fearless, Can-do attitude
• Results Orientation – Delivering progress toward our mission. Sense of urgency in solving problems.
• Entrepreneurial Spirit – Proactive. Ownership mindset.