Scientist I, Formulation

About Stoke:

Stoke Therapeutics (Nasdaq: STOK) is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke entered into a strategic collaboration with Biogen in 2025 to develop and commercialize zorevunersen for Dravet syndrome. Under the collaboration, Stoke retains exclusive rights for zorevunersen in the United States, Canada, and Mexico; Biogen receives exclusive rest of world commercialization rights

Stoke’s initial focus for its TANGO platform is on diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency).

Stoke has identified STK-002 as a clinical candidate for the potential treatment of autosomal dominant optic atrophy (ADOA), the most common inherited optic nerve disorder. The company is also pursuing a potential new medicine for Syngap1, a severe and rare neurodevelopmental disorder, in collaboration with Acadia Pharmaceuticals.

Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for the Company’s proprietary approach.

Position Purpose:

We are seeking a highly motivated and detail-oriented Formulation Scientist to join our Early Development team focused on oligonucleotide-based therapeutics. This role offers a unique opportunity to contribute to the design and development of innovative drug formulations at the preclinical and early clinical stages. You’ll work closely with cross-functional teams to support formulation screening, in vitro and in vivo formulation preparation, and process development for novel oligonucleotide candidates. This position will report into Senior Principal Scientist, Formulation Lead.

Key Responsibilities:

• Design and execute formulation studies for oligonucleotide drug products
• Prepare prototype formulations and conduct pre-formulation characterization (e.g., solubility, pH stability, buffer selection)
• Collaborate with analytical, process development, and manufacturing teams to ensure seamless tech transfer
• Support analytical testing and interpretation of data related to physical and chemical stability
• Maintain accurate and timely documentation of experiments, protocols, and results in electronic lab notebooks
• Contribute to the preparation of technical reports, presentations, and regulatory documentation
• Stay current with scientific literature and industry trends in oligonucleotide formulation and delivery
• Additional duties as assigned
  
  

Required Skills & Experience:

• PhD in Pharmaceutical Sciences, Chemistry, Biochemistry, or related field, Master’s degree with 6+ years of experience in formulation development, or Bachelor’s with 10+ years of experience
• Experience with nucleic acid-based therapeutics preferred
• Familiarity with oligonucleotide properties, degradation pathways, and formulation challenges
• Hands-on experience with lab techniques such as pH adjustment, UV spectroscopy, endotoxin and physical property measurement; hand-on experience with HPLC/UPLC is a plus
• Strong organizational skills and attention to detail
• Excellent communication and teamwork abilities
  
  

Location(s):

Stoke operates in Bedford, MA. This position is a lab-based position in our Bedford, MA location.

Travel:

This position will require approximately 5% travel.

Culture & Values:

At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.

Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging Committee (DIB) underscores the importance of DIB to who we are and what we do.

Benefits & Compensation:

At Stoke Therapeutics we are proud to offer comprehensive and competitive employee benefits, including medical, dental and vision insurance; life, long and short-term disability insurance; Paid Parental Leave; a 401K program with company match, unlimited vacation time, and an Employee Stock Purchase Program (ESPP). Compensation is market competitive for the industry and directly commensurate with experience. All positions are bonus and stock eligible.

Interested candidates: Please visit Stoke’s website to learn more and apply directly to the position listed on our Career Center.

For more information, visit stoketherapeutics.com or follow the company on X at @StokeTx.

All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.

Stoke participates in E-Verify.