Scientist I, Formulation and Process Development

Role Summary

We are seeking a Scientist I to join the tLNP drug product formulation and process development team. You will work on formulation and process development of tLNP drug products to support emerging research pipelines. The role is hands-on laboratory work based in San Diego, reporting to the Principal Scientist, with all duties performed in accordance with AbbVie's SOPs.

Responsibilities

• Develop novel formulation, conjugation and purification process for lipid nanoparticles based nucleic acid formulations with targeting modalities.
• Prepare, formulate, and characterize nucleic based complex lipid nanoparticle formulations.
• Design, execute, and analyze DOE-based experiments to develop and optimize novel LNP formulations and lyophilized product development.
• Perform investigations of aberrant results, determination of root causes, and recommend action plan to ensure process robustness.
• Maintain proper documentation of all experimental procedures and results, including batch records, protocols, Standard Operating Procedures (SOPs) and other manufacturing related documentation.
• Prepare technical reports and presentations which summarize procedures, study results, and data interpretation as needed.
• Works in cross-functional teams to deliver results in an accurate and time sensitive manner.

Qualifications

• Bachelor’s Degree or equivalent education with typically 5 years of experience, or Master’s Degree or equivalent education with typically two years of experience.
• Understanding of lipid-based delivery systems and formulation science principles.
• Hands-on experience working with nucleic acid and/or lipid nanoparticle-based formulations, complex/nanoparticle formulations, other biological formulation and lyophilization formulation development.
• Comfortable working in a highly innovative, changing, fast-paced environment with multi-task skills is required.
• Ability to work under pressure and tight deadlines. Has the discipline to stay focused and complete specific tasks.
• Detail oriented with good organizational skills.
• A team player with excellent verbal and written communication skills.

Additional Requirements

• Ability to work in a well-lit heated and/or air-conditioned indoor office and occasional laboratory setting with adequate ventilation. Light physical activity performing non-strenuous daily activities of a productive/technical nature. May require long periods of standing/sitting.