Scientist I

Role: Medicinal Chemistry Scientist I focused on designing and synthesizing small molecule therapeutics for cardiovascular and neuromuscular diseases. Responsibilities: perform rapid synthesis of drug candidates, contribute to next-generation compound design using medicinal chemistry, DMPK, and physicochemical data; develop purification methods; integrate biological and DMPK feedback into design decisions employing computational tools; collaborate across chemistry, biology, DMPK, and computational teams; document findings thoroughly. Qualifications: Ph.D. in Organic or Medicinal Chemistry (or M.S. with relevant experience); expertise in organic synthesis, analytical techniques (NMR, MS, HPLC); emerging proficiency in multi-parameter optimization and computational chemistry; strong communication skills. Preferred: experience with structure-based design and modern synthetic methods relevant to lead optimization. High-Value: focus on small molecule lead discovery for cardiovascular and neuromuscular indications, leveraging multidisciplinary collaboration, and applying advanced analytical and computational methods. Work setup: based in South San Francisco, CA, with expected salary range $135,000-$157,500, inclusive of stock options, benefits, and bonuses.