Scientist, DMPK
Alnylam Pharmaceuticals
August 14, 2026
On-site
Cambridge, MA
Clinical Research and Development
Key Responsibilities:
- Support DMPK strategy across drug discovery and development by designing, executing, and interpreting in vitro and in vivo ADME and PK/PD studies for siRNA and other therapeutic modalities.
- Apply quantitative pharmacology approaches—including non-compartmental analysis, compartmental PK/PD, PBPK, and mechanistic/systems modeling—to characterize drug disposition and exposure–response relationships.
- Integrate PK, PD, and biomarker data to inform candidate selection, human dose projection, and first-in-human dose predictions.
- Build, qualify, and clearly document models and simulations using tools such as Phoenix WinNonlin, Monolix, R, and other equivalent tools.
- Contribute to the design of preclinical and translational studies from discovery through clinical development.
- Collaborate cross-functionally (bioanalysis, chemistry, biology, toxicology, clinical pharmacology) to analyze data and communicate insights.
- Prepare clear analyses, reports, presentations, and contribute to regulatory submissions as needed.
- Complete projects timely with high scientific/data-quality standards.
- Stay current with emerging modeling methodologies and literature.
Qualifications:
- Ph.D. (0+ years) in a quantitative discipline in pharma sciences/pharmacology/engineering; or Masters (5+ years) / Bachelors (10+ years) in DMPK or quantitative pharmacology.
- Strong quantitative pharmacology and PK/PD modeling; hands-on non-compartmental and compartmental analysis.
- PBPK, population PK, or systems/mechanistic modeling (strong plus).
- Proficiency with Phoenix WinNonlin, Monolix, R (or equivalents).
- Solid ADME understanding; knowledge of oligonucleotide therapeutics (siRNA/ASO) or novel modalities (plus).
- Strong problem solving, adaptability, detail orientation, organization, and ability to manage multiple projects in a fast-paced team environment.
- Strong interpersonal skills and excellent verbal/written communication.
Benefits:
- Annual short-term incentive (bonus) and annual long-term incentive (equity).
- Medical, dental, vision; life/disability; lifestyle reimbursement; flexible spending/HSAs; 401(k) with generous match; paid time off, wellness days, holidays, recharge breaks; family resources and leave.
- Support DMPK strategy across drug discovery and development by designing, executing, and interpreting in vitro and in vivo ADME and PK/PD studies for siRNA and other therapeutic modalities.
- Apply quantitative pharmacology approaches—including non-compartmental analysis, compartmental PK/PD, PBPK, and mechanistic/systems modeling—to characterize drug disposition and exposure–response relationships.
- Integrate PK, PD, and biomarker data to inform candidate selection, human dose projection, and first-in-human dose predictions.
- Build, qualify, and clearly document models and simulations using tools such as Phoenix WinNonlin, Monolix, R, and other equivalent tools.
- Contribute to the design of preclinical and translational studies from discovery through clinical development.
- Collaborate cross-functionally (bioanalysis, chemistry, biology, toxicology, clinical pharmacology) to analyze data and communicate insights.
- Prepare clear analyses, reports, presentations, and contribute to regulatory submissions as needed.
- Complete projects timely with high scientific/data-quality standards.
- Stay current with emerging modeling methodologies and literature.
Qualifications:
- Ph.D. (0+ years) in a quantitative discipline in pharma sciences/pharmacology/engineering; or Masters (5+ years) / Bachelors (10+ years) in DMPK or quantitative pharmacology.
- Strong quantitative pharmacology and PK/PD modeling; hands-on non-compartmental and compartmental analysis.
- PBPK, population PK, or systems/mechanistic modeling (strong plus).
- Proficiency with Phoenix WinNonlin, Monolix, R (or equivalents).
- Solid ADME understanding; knowledge of oligonucleotide therapeutics (siRNA/ASO) or novel modalities (plus).
- Strong problem solving, adaptability, detail orientation, organization, and ability to manage multiple projects in a fast-paced team environment.
- Strong interpersonal skills and excellent verbal/written communication.
Benefits:
- Annual short-term incentive (bonus) and annual long-term incentive (equity).
- Medical, dental, vision; life/disability; lifestyle reimbursement; flexible spending/HSAs; 401(k) with generous match; paid time off, wellness days, holidays, recharge breaks; family resources and leave.