Scientist DMPK

Role Summary

Scientist DMPK

Location: Boston, MA

Responsibilities

• Work closely with the medicinal chemistry team to facilitate Nonclinical Development, focusing on optimizing properties for oral administration
• Represent Nonclinical Development to project teams and present interpretation of ADME data related to in vitro and in vivo animal PK and biotransformation
• Continually learn in vitro ADME and in vivo animal PK analysis
• Coordinate outsourced in vitro and in vivo DMPK studies
• Explore new technologies and capabilities in discovery DMPK space
• Provide strong written and oral communication to support internal data sharing, study reports, and regulatory documentation
• Work on multiple projects within a matrixed organizational structure
• Support the Nonclinical Development & Clinical Pharmacology team across multiple project phases, including lead discovery, lead optimization, and regulatory filings

Qualifications

• PhD or MS with 3+ years of drug discovery industry experience in Drug Metabolism, Pharmacokinetics, Pharmaceutical Chemistry, Toxicology, or related field
• Experience managing internal and external collaborations/service providers (CROs)
• Ability to build relationships with peers and partners outside of Nonclinical Development & Clinical Pharmacology to enable high team performance
• Demonstrates novel, innovative solutions to challenging problems with scientific discretion and integrity
• Strong collaboration and innovative skills across DMPK as a project team representative
• Experience in design, conduct, and interpretation of in vitro and in vivo ADME and animal PK studies
• Ability to work on site 100%