Scientist, DMPK

Role: DMPK scientist supporting drug discovery and development of siRNA and therapeutic modalities through ADME and PK/PD modeling. Responsibilities: design and interpret in vitro/in vivo ADME and PK/PD studies; apply quantitative pharmacology approaches (non-compartmental, PBPK, systems modeling); develop and report models to inform candidate selection, dose projection, and regulatory filings; collaborate with cross-functional teams; contribute to study design, data analysis, and regulatory documentation; stay current with modeling advances. Qualifications: Ph.D. in pharmaceutical sciences, pharmacology, biomedical engineering, or related field with 0+ years of experience, or equivalent industry experience (Masters 5+ yrs, Bachelors 10+ yrs); expertise in PK/PD modeling, non-compartmental analysis, proficiency with Phoenix WinNonlin, Monolix, R; solid understanding of ADME principles and experience with oligonucleotide therapeutics or novel modalities preferred. High-Value: focus on RNAi therapeutics, drug discovery, PK/PD modeling, regulatory support. Work setup: onsite in Cambridge, MA.