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Scientist - Cytometry & Imaging Sciences

Amgen
Remote friendly (South San Francisco, CA)
United States
Operations

Role Summary

Calibrate and operate multiparameter flow cytometers (including cell sorters), microscopes and related imaging platforms. Train others and develop additional relevant skills as appropriate. Contribute to high-complexity cytometry and imaging workflows to support research and development goals in a biosafety level 2+ laboratory.

Responsibilities

  • Operate analytical flow cytometry analyzers and sorters with primary emphasis, and cell imaging platforms as a secondary emphasis; identify instrument problems, perform basic troubleshooting/remediation, and oversee field engineer remediation when required.
  • Compile high-complexity multiparameter fluorophore panels for legacy and full-spectrum flow cytometers to maximize signal while minimizing fluorescence spillover.
  • Guide and train others on facility use and maintain personal accountability for prioritized projects.
  • Work in a biosafety level 2+ laboratory, maintain laboratory safety for all personnel, and initiate and complete risk assessments for new activities as appropriate.

Qualifications

  • Required: Doctorate degree (PhD) or PharmD or MD preferably with Cytometry experience; or Masterโ€™s degree with 2+ years of Cytometry experience; or Bachelorโ€™s degree with 4+ years of Cytometry experience.
  • Preferred: Education in the life sciences; prior experience working in a biopharmaceutical company or academic projects with a biopharmaceutical sponsor.
  • Preferred: Good documentation practices and scientific conduct as defined by standard operating procedures.
  • Preferred: Ability to leverage varied AI/ML analytical platforms as they emerge and work in a team structure with data scientists in synergy.
  • Preferred: Working knowledge of how to integrate flow and imaging cytometry efforts with adjacent single-cell technologies (e.g., RNA seq, CRISPR screens).

Skills

  • Operational proficiency with analytical flow cytometry analyzers and sorters and related imaging platforms
  • Panel design for legacy and full-spectrum flow cytometers to maximize signal and minimize spillover
  • Teaching and mentoring others; accountability for prioritized projects
  • Laboratory safety, risk assessment, and working in a biosafety level 2+ environment
  • Collaboration with data scientists and familiarity with AI/ML analytical platforms
  • Integration of flow and imaging cytometry with adjacent single-cell technologies