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Scientist, Cell Therapy Discovery

AstraZeneca
Full-time
On-site
Gaithersburg, MD
$87,200 - $130,800 USD yearly
Clinical Research and Development

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Role Summary

Scientist with expertise in Computational Biology applied to Cellular Therapy, Immunology, and/or Immuno-Oncology. Develop advanced computational models using omic datasets, design and conduct laboratory experiments, and generate and interpret scientific data in a collaborative environment. Based in Gaithersburg, MD.

Responsibilities

  • Plan, conduct, and troubleshoot discovery research experiments within a team environment.
  • Assess and report data with an understanding of its implications within the project context; independently formulate conclusions and determine future experiments.
  • Design, develop, and deploy AI-driven machine learning and deep learning models to extract knowledge from structured and unstructured data relevant to new therapies.
  • Provide technical instruction to the team and allocate administrative work where possible.
  • Work collaboratively in a matrix environment.
  • Prepare and deliver presentations within the Cell Therapy Unit and across other functions.
  • Ensure own work and peers' work comply with internal standards and external regulations.

Qualifications

  • Required: BS in a relevant discipline (e.g., Bioinformatics, Systems Biology, Applied Mathematics, Statistics, Data Science, Computer Science) or equivalent experience.
  • Required: Minimum of 2 years of experience in Cellular Therapy, Immunology, Immuno-Oncology, Computational Biology, and/or Data Science.
  • Required: Proficiency in Python and/or R.
  • Required: UNIX-based systems experience, high-performance computing (e.g., SLURM), and large-scale data management.
  • Required: Expertise in omics technologies and processing large-scale biological datasets (e.g., single-cell/spatial transcriptomics, in-house data sources).
  • Required: Deep understanding of AI, predictive modeling, and statistical methods for training ML models.
  • Required: Hands-on experience with T-cell functional characterization assays (in vitro cytotoxicity, proliferation, cytokine measurement, multi-parameter flow cytometry).
  • Required: Ability and motivation to drive projects to completion in a team environment.

Desirable Skills

  • Experience in drug development in an industry setting.