Scientist, Cell Biology

Role Summary

As a Scientist within our Cell Biology group, you will have a direct impact on our drug pipeline as a lab-based contributor and functional area lead within the project setting. Your work as a member of our experienced cross-functional team will drive discovery, characterization, and optimization of novel cell-based therapies.

Responsibilities

• Contribute to one or more pipeline programs, working collaboratively with cross-functional teams to ensure the timely generation and dissemination of critical program data to enable data-driven decisions.
• Design and execute experiments independently with minimal supervision, as well as effectively plan and organize work activities and prioritize task completion.
• Serve as a functional area lead within a project setting; helping to derive timelines, plan, and execute to help achieve project goals.
• Stay up to date with relevant technical and intellectual scientific expertise in tumor biology and cancer modelling, particularly as it relates to CAR-T cell biology or other cell-based therapies.

Qualifications

• Required: Master’s degree with 4–6+ years of research experience within the pharmaceutical industry, or PhD-level scientist from a relevant field with 0–2 years of industry experience.
• Specific backgrounds of interest are:
  • Chimeric Antigen Receptor (CAR) T-cells or alternative cell-based cancer therapeutics
  • T-cell signaling and/or cytokine signaling and cytokine biology
  • Solid Tumor Immunology (Tumor Infiltrating Lymphocytes, Myeloid Derived Suppressor Cells, Tumor Associated Macrophages, Regulatory T-cells)
• Expertise in manipulating immune cells, particularly T cells, including purification, transfection/transduction, activation and expansion.
• Experience with in vivo models of human cancer, including cell line derived xenografts or patient-derived xenografts.
• Expertise in complex immune cell assays including multiparameter flow cytometry, in vitro cell based assays (e.g., cytotoxicity, proliferation, degranulation), live cell analysis, and multiplex assays.
• Familiarity with methods to pre-clinically assess efficacy, specificity, and safety of CAR-T cells or other novel immuno-oncology agents.
• Commitment to ethical scientific investigations and rigorous experimental methods.
• Ability and desire to multitask and function in a fast-paced entrepreneurial environment.
• Interpersonal skills that promote a collaborative and productive lab environment.

Skills

• Manipulation of immune cells, particularly T cells, including purification, transfection/transduction, activation and expansion.
• In vivo cancer models (cell line derived xenografts or patient-derived xenografts).
• Complex immune cell assays (multiparameter flow cytometry, in vitro cytotoxicity, proliferation, degranulation), live cell analysis, and multiplex assays.
• Pre-clinical assessment of efficacy, specificity, and safety of CAR-T cells or other immuno-oncology agents.