Scientist - Biology

Role Summary

Join our Neuroscience Disease Area within Novartis Biomedical Research to drive human disease modeling and support drug discovery across multiple neurological disorders. This role focuses on developing iPSC-derived models and generating assays to advance preclinical programs in neurodegenerative, neuroinflammatory, and neuromuscular diseases.

Responsibilities

• Develop human iPSC-derived complex models of motor neurons and glia (microglia and astrocytes) to advance our Neuroscience preclinical program
• Generate cellular and biochemical assays for compound profiling as well as for drug-discovery target validation
• Characterize ex vivo mechanistic mouse model tissues for PKPD efficacy and for biomarker validation
• Collaborate with senior lab members, managers, and scientists to design, execute, and generate high-quality, reproducible data across multiple projects
• Analyze, interpret, and communicate/present scientific data within project teams and beyond, while maintaining accurate study records and ensuring prioritization of critical tasks
• Independently design experiments and advance assay development, while working in a highly collaborative team setting

Qualifications

• Senior Scientist I: Bachelor's and 4+ years or Master’s degree and 2+ years of industry or academic research experience in Neuroscience, Cell & Molecular Biology or Biochemistry (or equivalent) is required. Senior Scientist II: Bachelor's degree and 6+ years of experience or Master's degree and 4+ years of experience
• Expertise in drug-discovery flow-chart assay development, including leveraging human iPSC-derived disease models and ex vivo tissue analysis
• Proficiency in molecular biology techniques, such as RT-qPCR, ddPCR, in situ hybridization (ISH)/RNAscope, Western Blotting, ELISA and Immunofluorescence
• Experience in high-content imaging and analysis software. Knowledge of computer software and Microsoft applications (Word, Excel, PowerPoint, GraphPad Prism)
• Ability to work productively in a fast-paced environment, excellent communication skills, and a collaborative mindset

Skills

• Drug-discovery assay development
• iPSC-derived disease models
• Molecular biology techniques (RT-qPCR, ddPCR, ISH/RNAscope, Western Blotting, ELISA, Immunofluorescence)
• High-content imaging and data analysis
• Effective communication and teamwork

Education

• Relevant: Neuroscience, Cell & Molecular Biology, Biochemistry or closely related field
• Advanced degree (Master’s or PhD) preferred for higher levels

Additional Requirements

• Experience with in vivo PKPD evaluation and rodent handling/intracerebroventricular injections is preferred