Scientist, Biocatalysis & Protein Engineering

Role: Scientist in Biocatalysis & Protein Engineering focused on discovering, engineering, and optimizing enzymes for oligonucleotide and small-molecule manufacturing. Objectives include developing high-throughput screening platforms, enzyme characterization workflows, and advancing biocatalysts with improved activity, stability, and manufacturability, from discovery to process implementation. Responsibilities encompass designing enzyme discovery campaigns via directed evolution and rational design, developing automated screening assays, constructing enzyme libraries, and collaborating across functions and with external partners to support scalable enzyme transfer. Qualifications: Ph.D. in Biochemistry, Molecular Biology, or related field with extensive enzyme engineering experience; proficiency in molecular biology techniques, enzyme kinetics, and high-throughput screening; experience with automation and biocatalysis applications in pharmaceuticals is preferred. The role demands strong analytical, problem-solving, and cross-functional collaboration skills. High-Value: focus on enzyme engineering for oligonucleotide or small-molecule manufacturing, biocatalysis in pharmaceutical processes, and progressing enzymes through discovery to process development. Work setup: onsite at Kendall Square, Cambridge, MA, with an emphasis on collaboration and innovation.