Scientist - Bioassay Screening - Biotherapeutic Drug Discovery

Role Summary

Scientist - Bioassay Screening - Biotherapeutic Drug Discovery. The role focuses on supporting research teams across multiple therapeutic areas by miniaturizing, adapting and executing assays to screen biologics using state-of-the-art lab automation, with emphasis on fast-paced, collaborative environments and cross-team collaboration.

Responsibilities

• Interface with multiple project teams to adapt bioassays to mid-high throughput automated formats (96W/384W), validate and execute screens, and identify hits for biologics discovery; develop de novo cell-based assays as needed.
• Leverage AI/ML-driven experimental design and adaptive screening strategies to compress assay development timelines and generate insights for biologics discovery strategies.
• Apply specialized software tools to analyze biological activity, evaluate assay performance statistically, and generate data reports.
• Identify and evaluate procedures or technologies to bolster productivity of antibody discovery and protein engineering teams; integrate emerging computational tools and automation technologies into workflows, including AI-driven optimization platforms and automated design-of-experiment software.
• Present results to collaborators, participate in project team meetings, and present at internal forums.
• Maintain clear, organized data, SOPs, and electronic notebook entries with attention to detail.

Qualifications

• Required: B.S. or M.S. in biology, biotechnology, biochemistry, molecular biology, or related field with 3+ years of relevant research experience in assay development and execution, preferably in drug discovery.

Additional Qualifications

• Proficient in assay development, optimization, miniaturization and troubleshooting of plate-based bioassays in 96/384W formats; ability to reduce optimization timelines through data-driven approaches.
• Expertise in diverse assay methods and technologies (e.g., reporter, FRET/BRET, AlphaLISA, HTRF, internalization, co-culture bioassays).
• Strong cell culture techniques with understanding of cellular signaling pathways.
• Experience with design-of-experiment, visualization, and statistical analysis software (e.g., Genedata Screener, TIBCO Spotfire, GraphPad Prism, JMP).
• Ability to adapt to new responsibilities and tackle challenges.
• Experience operating automated instrumentation in a high-throughput screening environment; enthusiasm for integrating AI/ML tools into workflows.
• Curiosity and initiative in adopting emerging technologies to improve efficiency or capabilities.
• Detail-oriented, organized, able to prioritize multiple projects to meet timelines.
• Excellent written and oral communication; able to work in a highly collaborative team.
• Highly motivated, capable of independent work, capable of mastering new skills and technologies; preferred.
• Experience with advanced imaging, flow cytometry or microfluidics-based assays is a plus.

Education

• Educational requirements listed in Basic Qualifications: B.S. or M.S. in biology, biotechnology, biochemistry, molecular biology, or related field.