Scientist, Bioanalytical (Large Molecule)

Role Summary

As a Bioanalytical Scientist within Research and Breakthrough Innovation, you will support Elanco’s Large Molecule Assay Development team through the development, validation, and execution of ligand-binding assays (LBAs). This laboratory-based role focuses on generating high-quality bioanalytical data to support preclinical and clinical programs involving monoclonal antibodies and other protein therapeutics. You will work in a highly collaborative, cross-functional environment and play a key role in advancing innovative animal health solutions.

Responsibilities

• Design, develop, optimize, and validate ligand-binding assays (ELISA, MSD, Gyros) for quantification of monoclonal antibodies and other protein therapeutics in biological matrices
• Execute fit-for-purpose bioanalytical methods in accordance with internal SOPs and global regulatory guidelines, evaluating accuracy, precision, selectivity, sensitivity, and stability
• Analyze preclinical and clinical study samples and deliver high-quality, reliable data to project teams
• Characterize, conjugate, and manage critical assay reagents to ensure long-term consistency and performance
• Independently troubleshoot assay challenges and evaluate new technologies to improve sensitivity, throughput, and robustness

Qualifications

• Required: Ph.D. in Immunology, Biochemistry, Biology, or a related discipline, or MS with 3+ years of relevant industry experience, or BS with 5+ years of relevant industry experience
• Required: Demonstrated hands-on experience developing, validating, and executing ligand-binding assays
• Required: Strong understanding of pharmacokinetics principles for biologic therapeutics
• Required: Proficiency with immunoassay platforms, with ELISA experience
• Preferred: Experience with advanced immunoassay platforms such as MSD, Gyros, or Quanterix
• Preferred: Experience developing and validating immunogenicity (ADA) assays
• Preferred: Familiarity with cell-based neutralizing antibody (NAb) assays
• Preferred: Strong data analysis skills and experience with bioanalytical software tools (e.g., SoftMax Pro, Benchling)
• Preferred: Demonstrated scientific rigor, problem-solving ability, and attention to detail

Education

• Ph.D. in Immunology, Biochemistry, Biology, or a related discipline, or MS with 3+ years of relevant industry experience, or BS with 5+ years of relevant industry experience

Additional Requirements

• Location: Indianapolis, IN (Hybrid Work Environment)
• Travel: Minimal