Scientist – Preclinical Team

Role Summary

Scientist to join the Pre-Clinical team to support the progression of therapeutic programs through the design, execution, and optimization of in vivo research activities and preclinical studies. This role requires deep expertise in in vivo methodologies, strong technical skills, and the ability to perform complex operations in a regulated environment.

Responsibilities

• Partner with the Principal Scientist and Director to provide preclinical expertise, including animal handling and study design
• Plan, execute, and analyze in vivo and ex vivo studies to support program objectives
• Perform cell-based assays and tissue analyses from in vivo studies; compile and report results
• Conduct survival surgeries and establish rodent models using aseptic techniques
• Develop, characterize, and implement new animal models to enhance pharmacology study effectiveness
• Maintain detailed, audit-ready documentation of all studies to ensure data integrity and traceability
• Optimize and implement best practices for in vivo research, including model selection, dosing strategies, and sample/data collection techniques
• Ensure compliance with regulatory guidelines and ethical standards for all preclinical activities
• Evaluate and integrate new technologies and platforms to improve study efficiency and quality
• Perform and interpret preclinical imaging studies (e.g., IVIS)
• Contribute to a team culture that promotes continuous improvement, ownership, and inclusion

Qualifications

• Required: Ph.D. in a relevant scientific discipline with expertise in nonclinical operations within drug discovery and development
• Required: Hands-on experience with cell biology techniques, including RNA/DNA extraction, PCR, Western blot, ELISA, and interventional assays for small molecules and biologics
• Preferred: Experience across diverse therapeutic modalities (small molecules, biologics, nucleic acid therapeutics, gene therapy)
• Preferred: Familiarity with age-related disease models (inflammation, metabolic disorders, neurodegeneration, muscle atrophy, bone/joint deficits)
• Preferred: Experience with metabolic chambers, behavioral assays, and related data analysis

Additional Requirements

• On-site laboratory environment with routine handling of animals and biological samples
• Prolonged periods of standing and performing surgical or technical procedures
• Ability to lift laboratory materials up to 20 pounds