Scientist--ADC Biology (Non-PhD)

Role Summary

Scientist--ADC Biology (Non-PhD) role focusing on the development of next-generation antibody-drug conjugates for cancer therapy, spanning early discovery to clinical development. Design and implement robust biological assays to evaluate payload chemotypes, identify susceptible cancer indications, and optimize pairing with tumor-associated antigens. Analyze and communicate experimental data to multidisciplinary teams and support regulatory submissions and clinical advancement.

Responsibilities

• Apply cellular, proteomic, and molecular biology techniques to preclinical cancer biology research
• Execute flow cytometry, immunohistochemistry, cytotoxicity assays, reporter assays, ELISA, alpha-LISA, western blotting, WES, and in vitro PD assays
• Investigate ADC targets, linker payloads, and novel mechanisms of action through complex assay development and optimization
• Independently design, execute, analyze, and document key experiments to enable go/no-go decisions; present findings to diverse audiences
• Provide leadership within technical area; may train others
• Maintain rigorous experimental records using electronic laboratory notebooks

Qualifications

• Required: Bachelor‚Äôs degree in Biology, Biochemistry, Engineering, Immunology or related field with 6+ years of relevant industry ADC Biology or small molecule experience OR Master‚Äôs degree with 4+ years of relevant experience
• Required: Experience with tissue culture and diverse molecular biology techniques
• Required: Experience with protein quantification methods (e.g., WES, western blotting)
• Required: Proficiency in flow cytometry analysis
• Required: Ability to work in a rapidly evolving environment; independence and teamwork
• Required: Strong written and verbal communication; excellent organization and planning
• Preferred: Knowledge of therapeutic antibodies, protein degraders, and/or ADCs
• Preferred: Knowledge of epigenetics, signal transduction, and/or metastasis pathways
• Preferred: Experience with cell-based assay development for screening; immunohistochemistry/immunofluorescence/imaging
• Preferred: Experience with omics data analysis; software for data analysis

Skills

• Cellular, proteomic, and molecular biology techniques
• Flow cytometry, immunohistochemistry, ELISA, western blotting, WES
• Data analysis and interpretation; clear scientific communication
• Independent experimental design and problem solving

Education

• Bachelor‚Äôs or Master‚Äôs degree in relevant field as specified in qualifications

Additional Requirements

• Lifting, sitting, standing, walking, bending; ability to perform mathematical calculations and complex data analysis
• Occasional non-standard hours and travel (1‚Äì2 times per year); on-premise work location