Scientist 1, Chemistry

Role Summary

The Scientist 1 will be responsible for contributing to the success of Crinetics’ growing drug discovery projects and working within the Chemistry team. This individual will be responsible for both the design and synthesis of small-molecule drug candidates and should be highly proficient in the analysis of diverse data sets to build/drive Crinetics’s medicinal chemistry strategy.

Responsibilities

• Independently design, plan and execute synthesis, purification and submission of small molecule drug candidates and other molecules
• Troubleshoot chemistry problems independently
• Generate effective hypotheses to pursue, followed by experimental planning and execution
• Prepare and organize data for presentations and be able to present written and oral reports to within the team and cross-functionally
• Participate in group discussion to exchange ideas among peers
• Prioritize chemistry efforts to ensure efficient and timely progression of projects to meet company goals
• Conduct and coordinate lab tasking and responsibilities to ensure a smooth and safe operation
• Stay current in both synthetic organic and medicinal chemistry literature to support company research objectives

Qualifications

• Ph.D. in synthetic organic chemistry
• Highly skilled in methodology development and multistep synthesis with demonstration of excellent problem-solving skills
• Strong track record of achievement in synthesis of complex molecules with state-of-the-art knowledge of modern synthetic methodologies and analytical and purification techniques
• Proven track record of creative thinking and consistent delivery as demonstrated by publication/presentation/patent record
• Excellent written and oral communication skills, enthusiasm, integrity, self-motivation, strong interpersonal skills, ability to interact within a multidisciplinary team
• Responds well to scientific challenges and applies significant rigor to their own work
• Proficient in using chemistry related software and database such as ChemDraw, SciFinder, Reaxys
• Laboratory experience with: Flash column systems, NMR spectroscopy, thin layer chromatography, handling pyrophoric materials, LC/MS

Education

• Ph.D. in synthetic organic chemistry

Additional Requirements

• Position Location: Onsite role in San Diego, CA
• Physical Demands and Work Environment: Some lifting to 25 lbs; ability to sit at a desk for long periods; laboratory environment requirements
• Travel: Up to 5% travel may be required