Scientific Director - Sustainable Peptide Process Chemistry – SMDD

Role Summary

Scientific Director - Sustainable Peptide Process Chemistry – SMDD at Lilly, leading sustainable peptide process development and commercialization efforts within the Synthetic Molecule Design and Development division. Drive multi-kg scale development, mentor partners, and guide next-generation, environmentally responsible peptide manufacturing for incretin therapies.

Responsibilities

• Lead a team of peptide chemists in designing and developing sustainable synthetic peptide processes.
• Provide oversight for multi-kg scale peptide process development at contract manufacturing organizations (CMOs) and lead internal development activities.
• Educate and mentor CMOs on best practices for greener peptide development and manufacturing.
• Present research findings at internal forums and external conferences; publish in high-quality, peer-reviewed journals.
• Communicate both the technical and business implications of research outcomes clearly and effectively.
• Apply expertise in Tag-Assisted Liquid-Phase Peptide Chemistry to enable scalable and efficient peptide synthesis.

Qualifications

• Ph.D. in Chemistry or related field with 7+ years of pharmaceutical industry experience, or
• B.S./M.S. in Chemistry with 12+ years of relevant experience in industry or academia.

Skills

• Demonstrate excellence in multiple modes of peptide synthesis, including hybrid SPPS/LPPS chemistry.
• Experience leading teams of scientists in peptide route development.
• Design, development, and implementation of sustainable, innovative processes for complex peptide synthesis, with a focus on PFAS-free conditions.
• Green chemistry and engineering solutions to improve environmental footprint and reduce PMI.
• Familiarity with chromatography, mass spectrometry, optical spectroscopy, and peptide automation.
• Strong technical problem-solving ability and motivation to succeed in team environments.
• Track record of innovative scientific research with publications and external conference presentations.

Education

• Ph.D. in Chemistry or related field (preferred) or an equivalent combination of education and experience as detailed in Basic Qualifications.

Additional Requirements

• Strong interpersonal skills and a sustained track record of collaboration.
• Ability to learn and apply new technical knowledge to meet evolving project needs.
• Demonstrated flexibility, prioritization skills, and the ability to work effectively in dynamic environments.
• Proven leadership capabilities, especially in cross-functional or global team settings.
• Ability to balance multiple priorities and navigate ambiguity effectively.

Additional Information

• Physical Demands/Travel: The physical demands are consistent with a lab and office environment. Travel: 0–10%